1fwj Summary


PDB entry 1fwj (supersedes 1kau)


The structure was published by Pearson, M.A., Michel, L.O., Hausinger, R.P., and Karplus, P.A., in 1997 in a paper entitled "Structures of Cys319 variants and acetohydroxamate-inhibited Klebsiella aerogenes urease." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 1997.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely UREASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterononamer.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A UREASE P18316 (1-100) (URE3_ENTAE)search Enterobacter aerogenessearch 100% 100 100%
B UREASE P18315 (1-106) (URE2_ENTAE)search Enterobacter aerogenessearch 95% 106 95%
C UREASE P18314 (1-567) (URE1_ENTAE)search Enterobacter aerogenessearch 100% 567 99%

This entry contains 3 unique UniProt proteins:

UniProt accession Name Organism PDB
P18316 (1 - 100) UREASE Enterobacter aerogenes
P18315 (1 - 106) UREASE Enterobacter aerogenes
P18314 (1 - 567) UREASE Enterobacter aerogenes

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P18316) Urease, gamma-subunitsearch Urease, subunit Asearch PF00547: Urease, gamma subunitsearch
B (P18315) Urease, beta-subunitsearch Urease, subunit Bsearch PF00699: Urease beta subunitsearch
C (P18314) alpha-Subunit of ureasesearch, alpha-subunit of urease, catalytic domainsearch Urease, subunit C, domain 1search, Metal-dependent hydrolasessearch PF00449: Urease alpha-subunit, N-terminal domainsearch, PF01979: Amidohydrolase familysearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P18316) urea metabolic processsearch urea catabolic processsearch nickel cation bindingsearch urease activitysearch protein bindingsearch hydrolase activitysearch cytoplasmsearch
B (P18315) urea catabolic processsearch urease activitysearch hydrolase activitysearch cytoplasmsearch
C (P18314) nitrogen compound metabolic processsearch urea metabolic processsearch urea catabolic processsearch nickel cation bindingsearch urease activitysearch hydrolase activitysearch protein bindingsearch hydrolase activity, acting on carbon-nitrogen (but not peptide) bondssearch metal ion bindingsearch cytoplasmsearch

Chain InterPro annotation
A Urease, gamma/gamma-beta subunitsearch Urease, gamma subunitsearch
B Urease, beta subunitsearch
C Urease, alpha subunitsearch Amidohydrolase 1search Metal-dependent hydrolase, composite domainsearch Urease alpha-subunit, N-terminal domainsearch Urease active sitesearch Urease, alpha subunit, C-terminalsearch Urease nickel binding sitesearch