1fvt Summary

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THE STRUCTURE OF CYCLIN-DEPENDENT KINASE 2 (CDK2) IN COMPLEX WITH AN OXINDOLE INHIBITOR

The structure was published by Davis, S.T., Benson, B.G., Bramson, H.N., et al., Veal, J.M., Walker, D.H., and Kuyper, L.F., in 2001 in a paper entitled "Prevention of chemotherapy-induced alopecia in rats by CDK inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2000.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of CELL DIVISION PROTEIN KINASE 2. This molecule has the UniProt identifier P24941 (CDK2_HUMAN)search. The sample contained 298 residues which is 100% of the natural sequence. Out of 298 residues 281 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 94%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) CELL DIVISION PROTEIN KINASE 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P24941) protein phosphorylationsearch positive regulation of transcription, DNA-templatedsearch Ras protein signal transductionsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch mitotic cell cyclesearch meiotic nuclear divisionsearch G1/S transition of mitotic cell cyclesearch cellular response to nitric oxidesearch cellular response to DNA damage stimulussearch G2/M transition of mitotic cell cyclesearch DNA repairsearch positive regulation of DNA-dependent DNA replication initiationsearch mitotic nuclear divisionsearch cell cyclesearch DNA replicationsearch centrosome duplicationsearch phosphorylationsearch histone phosphorylationsearch regulation of gene silencingsearch blood coagulationsearch positive regulation of cell proliferationsearch cell divisionsearch potassium ion transportsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch mitotic G1 DNA damage checkpointsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch ATP bindingsearch protein bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch protein serine/threonine kinase activitysearch histone kinase activitysearch cyclin bindingsearch metal ion bindingsearch kinase activitysearch transferase activitysearch nucleotide bindingsearch nucleoplasmsearch cyclin-dependent protein kinase holoenzyme complexsearch cytosolsearch X chromosomesearch nucleussearch endosomesearch Cajal bodysearch Y chromosomesearch cytoplasmsearch transcription factor complexsearch microtubule organizing centersearch cytoskeletonsearch centrosomesearch condensed chromosomesearch chromosome, telomeric regionsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch