1fvr Summary



The structure was published by Shewchuk, L.M., Hassell, A.M., Ellis, B., et al., Kadwell, S.H., McKee, D.D., and Moore, J.T., in 2000 in a paper entitled "Structure of the Tie2 RTK domain: self-inhibition by the nucleotide binding loop, activation loop, and C-terminal tail." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2000.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of TYROSINE-PROTEIN KINASE TIE-2.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A TYROSINE-PROTEIN KINASE TIE-2 Q02763 (808-1124) (TIE2_HUMAN)search Homo sapienssearch < 90% 327 91%
B TYROSINE-PROTEIN KINASE TIE-2 Q02763 (808-1124) (TIE2_HUMAN)search Homo sapienssearch < 90% 327 91%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q02763 (808 - 1124) TYROSINE-PROTEIN KINASE TIE-2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (Q02763) protein tyrosine kinase activitysearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein phosphorylationsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch