1fur Summary

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FUMARASE MUTANT H188N WITH BOUND SUBSTRATE L-MALATE AT PUTATIVE ACTIVATOR SITE

The structure was published by Weaver, T., Lees, M., and Banaszak, L., in 1997 in a paper entitled "Mutations of fumarase that distinguish between the active site and a nearby dicarboxylic acid binding site." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.95 Å and deposited in 1997.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of FUMARASE C.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A FUMARASE C P05042 (1-467) (FUMC_ECOLI)search Escherichia coli K-12search 100% 467 97%
B FUMARASE C P05042 (1-467) (FUMC_ECOLI)search Escherichia coli K-12search 100% 467 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P05042 (1 - 467) FUMARASE C Escherichia coli

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P05042) L-aspartase/fumarasesearch Fumarase/aspartase (N-terminal domain)search, Fumarase/aspartase (Central domain)search, Fumarase/aspartase (C-terminal domain)search PF00206: Lyasesearch, PF10415: Fumarase C C-terminussearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P05042) tricarboxylic acid cyclesearch fumarate metabolic processsearch response to oxidative stresssearch metabolic processsearch lyase activitysearch catalytic activitysearch fumarate hydratase activitysearch cytoplasmsearch tricarboxylic acid cycle enzyme complexsearch

Chain InterPro annotation
A, B Fumarate lyase familysearch Fumarate hydratase, class IIsearch L-Aspartase-likesearch Fumarase C, C-terminalsearch Fumarate lyase, conserved sitesearch Fumarate lyase, N-terminalsearch Fumarase/histidase, N-terminalsearch