› 1ftt

Solution NMR

THYROID TRANSCRIPTION FACTOR 1 HOMEODOMAIN (RATTUS NORVEGICUS)

Released:
DOI: 10.2210/pdb1ftt/pdb
PDB entry 1ftt coloured by chain, ensemble of 20 models, front view.
PDB entry 1ftt coloured by chain, ensemble of 20 models, side view.
PDB entry 1ftt coloured by chain, ensemble of 20 models, top view.
Source organism: Rattus norvegicus
Primary publication:
Analysis of the solution structure of the homeodomain of rat thyroid transcription factor 1 by 1H-NMR spectroscopy and restrained molecular mechanics.
Esposito G, Fogolari F, Damante G, Formisano S, Tell G, Leonardi A, Di Lauro R, Viglino P
Eur J Biochem 241 101-13 (1996)
PMID: 8898894

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149960 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Homeobox protein Nkx-2.1 Chain: A
Molecule details ›
Chain: A
Length: 68 amino acids
Theoretical weight: 8.46 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P23441 (Residues: 161-227; Coverage: 18%)
Gene names: Nkx-2.1, Nkx2-1, Titf1, Ttf-1, Ttf1
Sequence domains: Homeodomain
Structure domains: Homeodomain-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Expression system: Escherichia coli BL21

Quick links

Citations

3 review citations

Lung organogenesis.
Warburton et al. (2010)
2 more

5 mentions without citation

The DNA-binding region of RAG 1 is not a homeodomain.
Banerjee-Basu et al. (2002)
4 more