spacer
EBI PDBe PDBeView

PDBe Entry: 1ftq view

STRUCTURES OF GLYCOGEN PHOSPHORYLASE-INHIBITOR COMPLEXES AND THE IMPLICATIONS FOR STRUCTURE-BASED DRUG DESIGN
Summary
Header TRANSFERASEsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 2.35 Å, R-factor: 17.7%, Free R-factor: 22.8%, Spacegroup: P 43 21 2
Released 04/10/2000, deposition: 13/09/2000, last revision: 24/02/2009
Authors Watson, K.A.search; Tsitsanou, K.E.search; Gregoriou, M.search; Zographos, S.E.search; Skamnaki, V.T.search; Oikonomakos, N.G.search; Fleet, G.W.search; Johnson, L.N.search
Primary citation Kinetic and crystallographic studies of glucopyranose spirohydantoin and glucopyranosylamine analogs inhibitors of glycogen phosphorylase.
PROTEINSsearch vol:61, pag:966-983 (2005) [PubMed ID 16222658 ]search
Keywords TRANSFERASEsearch, GLYCOGEN PHOSPHORYLASEsearch, INHIBITOR COMPLEXsearch, CATALYTIC SITEsearch, DESIGNsearch
EC 2.4.1.1 ExPASy BRENDA search (A)
Organism Oryctolagus cuniculus(rabbit) 9986search(A)
UniProt Glycogen phosphorylase, muscle form (EC 2.4.1.1) (Myophosphorylase) P00489search (A)
Solvent A
Related entries 1b4d, 1ggn, 1fs4, 1ftw, 1fty, 1fu4, 1fu7, 1fu8
Polymers
Id Name Type UniProt Residues Observed
A GLYCOGEN PHOSPHORYLASE Protein P00489 (PYGM_RABIT)search
 842 98%
Heterogens
Id Name Ligands
A SUGAR (3-AMINO-8,9,10-TRIHYDROXY-7-HYDROXYMETHYL-6-OXA-1,3-DIAZA-SPIRO[4.5]DECANE-2,4-DIONE) GL2 search
A PYRIDOXAL-5'-PHOSPHATE PLP search
A INOSINIC ACID IMP search
spacer