1fss Summary

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ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH FASCICULIN-II

There is a Quite Interesting Protein Structure article for this entry.

The structure was published by Harel, M., Kleywegt, G.J., Ravelli, R.B., Silman, I., and Sussman, J.L., in 1995 in a paper entitled "Crystal structure of an acetylcholinesterase-fasciculin complex: interaction of a three-fingered toxin from snake venom with its target." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.0 Å and deposited in 1995.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely ACETYLCHOLINESTERASE and FASCICULIN II.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A ACETYLCHOLINESTERASE P04058 (22-558) (ACES_TORCA)search Torpedo californicasearch 94% 537 99%
B FASCICULIN II P0C1Z0 (1-61) (TXFA2_DENAN)search Dendroaspis angusticepssearch 100% 61 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P04058 (22 - 558) ACETYLCHOLINESTERASE Torpedo californica
P0C1Z0 (1 - 61) FASCICULIN II Dendroaspis angusticeps

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P04058) Acetylcholinesterase-likesearch Rossmann foldsearch PF00135: Carboxylesterase familysearch
B (P0C1Z0) Snake venom toxinssearch CD59search PF00087: Snake toxinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P04058) acetylcholinesterase activitysearch carboxylic ester hydrolase activitysearch hydrolase activitysearch cholinesterase activitysearch plasma membranesearch anchored component of membranesearch synapsesearch cell junctionsearch membranesearch neurotransmitter catabolic processsearch acetylcholine catabolic process in synaptic cleftsearch
B (P0C1Z0) extracellular regionsearch modification of morphology or physiology of other organismsearch

Chain InterPro annotation
A Acetylcholinesterase, fish/snakesearch Cholinesterasesearch Carboxylesterase, type Bsearch Carboxylesterase type B, conserved sitesearch Carboxylesterase type B, active sitesearch Alpha/Beta hydrolase foldsearch
B Snake toxinsearch Snake toxin, conserved sitesearch