1fsr Summary



The structure was published by Cox, J.D., Hunt, J.A., Compher, K.M., Fierke, C.A., and Christianson, D.W., in 2000 in a paper entitled "Structural influence of hydrophobic core residues on metal binding and specificity in carbonic anhydrase II." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2000.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of CARBONIC ANHYDRASE II.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE II P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 99%
B CARBONIC ANHYDRASE II P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) CARBONIC ANHYDRASE II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P00918) carbonate dehydratase activitysearch zinc ion bindingsearch lyase activitysearch protein bindingsearch metal ion bindingsearch angiotensin-activated signaling pathwaysearch response to pHsearch response to estrogensearch bicarbonate transportsearch regulation of anion transportsearch response to steroid hormonesearch one-carbon metabolic processsearch morphogenesis of an epitheliumsearch positive regulation of synaptic transmission, GABAergicsearch kidney developmentsearch positive regulation of bone resorptionsearch response to organic substancesearch response to zinc ionsearch positive regulation of osteoclast differentiationsearch regulation of intracellular pHsearch positive regulation of dipeptide transmembrane transportsearch small molecule metabolic processsearch odontogenesis of dentin-containing toothsearch positive regulation of cellular pH reductionsearch secretionsearch regulation of chloride transportsearch cytoplasmsearch plasma membranesearch cytosolsearch extracellular spacesearch myelin sheathsearch microvillussearch membranesearch basolateral plasma membranesearch extracellular vesicular exosomesearch apical part of cellsearch axonsearch

Chain InterPro annotation
A, B Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch