1fs2 Summary

pdbe.org/1fs2
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INSIGHTS INTO SCF UBIQUITIN LIGASES FROM THE STRUCTURE OF THE SKP1-SKP2 COMPLEX

The structure was published by Schulman, B.A., Carrano, A.C., Jeffrey, P.D., et al., Harper, J.W., Pagano, M., and Pavletich, N.P., in 2000 in a paper entitled "Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2000.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely SKP2 and SKP1.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A SKP2 Q13309 (89-398) (SKP2_HUMAN)search Homo sapienssearch < 90% 272 95%
C SKP2 Q13309 (89-398) (SKP2_HUMAN)search Homo sapienssearch < 90% 272 95%
B SKP1 P63208 (1-147) (SKP1_HUMAN)search Homo sapienssearch 98% 141 90%
D SKP1 P63208 (1-147) (SKP1_HUMAN)search Homo sapienssearch 98% 141 90%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q13309 (89 - 398) SKP2 Homo sapiens
P63208 (1 - 147) SKP1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C F-box domainsearch, Cyclin A/CDK2-associated p19, Skp2search Ribonuclease Inhibitorsearch F-box-likesearch
B, D (P63208) Skp1 dimerisation domain-likesearch, BTB/POZ domainsearch Potassium Channel Kv1.1; Chain Asearch PF01466: Skp1 family, dimerisation domainsearch, PF03931: Skp1 family, tetramerisation domainsearch

Chain ID Biological process (GO)
B, D (P63208) ubiquitin-dependent protein catabolic processsearch

Chain InterPro annotation
A, C F-box domainsearch
B, D S-phase kinase-associated protein 1-likesearch BTB/POZ foldsearch SKP1 component, dimerisationsearch SKP1 component, POZ domainsearch S-phase kinase-associated protein 1search