1fro Summary



The structure was published by Cameron, A.D., Olin, B., Ridderstrom, M., Mannervik, B., and Jones, T.A., in 1997 in a paper entitled "Crystal structure of human glyoxalase I--evidence for gene duplication and 3D domain swapping." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 1997.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of LACTOYLGLUTATHIONE LYASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A LACTOYLGLUTATHIONE LYASE Q04760 (2-184) (LGUL_HUMAN)search Homo sapienssearch 99% 183 96%
B LACTOYLGLUTATHIONE LYASE Q04760 (2-184) (LGUL_HUMAN)search Homo sapienssearch 99% 183 96%
C LACTOYLGLUTATHIONE LYASE Q04760 (2-184) (LGUL_HUMAN)search Homo sapienssearch 99% 183 96%
D LACTOYLGLUTATHIONE LYASE Q04760 (2-184) (LGUL_HUMAN)search Homo sapienssearch 99% 183 96%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q04760 (2 - 184) LACTOYLGLUTATHIONE LYASE Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D (Q04760) Glyoxalase I (lactoylglutathione lyase)search 2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1search PF00903: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamilysearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B, C, D (Q04760) lactoylglutathione lyase activitysearch lyase activitysearch metal ion bindingsearch zinc ion bindingsearch negative regulation of apoptotic processsearch regulation of transcription from RNA polymerase II promotersearch carbohydrate metabolic processsearch osteoclast differentiationsearch glutathione metabolic processsearch methylglyoxal metabolic processsearch extracellular vesicular exosomesearch cytoplasmsearch

Chain InterPro annotation
A, B, C, D Glyoxalase/fosfomycin resistance/dioxygenase domainsearch Glyoxalase Isearch Glyoxalase I, conserved sitesearch Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenasesearch