1fqv Summary

pdbe.org/1fqv
spacer

Insights into scf ubiquitin ligases from the structure of the skp1-skp2 complex

The structure was published by Schulman, B.A., Carrano, A.C., Jeffrey, P.D., et al., Harper, J.W., Pagano, M., and Pavletich, N.P., in 2000 in a paper entitled "Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2000.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely SKP2 and SKP1.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A SKP2 Q13309 (89-424) (SKP2_HUMAN)search Homo sapienssearch < 90% 336 96%
C SKP2 Q13309 (89-424) (SKP2_HUMAN)search Homo sapienssearch < 90% 336 96%
E SKP2 Q13309 (89-424) (SKP2_HUMAN)search Homo sapienssearch < 90% 336 96%
G SKP2 Q13309 (89-424) (SKP2_HUMAN)search Homo sapienssearch < 90% 336 96%
I SKP2 Q13309 (89-424) (SKP2_HUMAN)search Homo sapienssearch < 90% 336 96%
K SKP2 Q13309 (89-424) (SKP2_HUMAN)search Homo sapienssearch < 90% 336 96%
M SKP2 Q13309 (89-424) (SKP2_HUMAN)search Homo sapienssearch < 90% 336 96%
O SKP2 Q13309 (89-424) (SKP2_HUMAN)search Homo sapienssearch < 90% 336 96%
B SKP1 P63208 (1-69) (SKP1_HUMAN)search ,
P63208 (83-163) (SKP1_HUMAN)search
Homo sapienssearch ,
Homo sapienssearch
98% ,
98%
149 91%
D SKP1 P63208 (1-69) (SKP1_HUMAN)search ,
P63208 (83-163) (SKP1_HUMAN)search
Homo sapienssearch ,
Homo sapienssearch
98% ,
98%
149 91%
F SKP1 P63208 (1-69) (SKP1_HUMAN)search ,
P63208 (83-163) (SKP1_HUMAN)search
Homo sapienssearch ,
Homo sapienssearch
98% ,
98%
149 91%
H SKP1 P63208 (1-69) (SKP1_HUMAN)search ,
P63208 (83-163) (SKP1_HUMAN)search
Homo sapienssearch ,
Homo sapienssearch
98% ,
98%
149 91%
J SKP1 P63208 (1-69) (SKP1_HUMAN)search ,
P63208 (83-163) (SKP1_HUMAN)search
Homo sapienssearch ,
Homo sapienssearch
98% ,
98%
149 91%
L SKP1 P63208 (1-69) (SKP1_HUMAN)search ,
P63208 (83-163) (SKP1_HUMAN)search
Homo sapienssearch ,
Homo sapienssearch
98% ,
98%
149 91%
N SKP1 P63208 (1-69) (SKP1_HUMAN)search ,
P63208 (83-163) (SKP1_HUMAN)search
Homo sapienssearch ,
Homo sapienssearch
98% ,
98%
149 91%
P SKP1 P63208 (1-69) (SKP1_HUMAN)search ,
P63208 (83-163) (SKP1_HUMAN)search
Homo sapienssearch ,
Homo sapienssearch
98% ,
98%
149 91%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q13309 (89 - 424) SKP2 Homo sapiens
P63208 (1 - 69) SKP1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C, E, G, I, K, M, O F-box domainsearch, Cyclin A/CDK2-associated p19, Skp2search Ribonuclease Inhibitorsearch F-box-likesearch
B, D, F, H, J, L, N, P (P63208) BTB/POZ domainsearch, Skp1 dimerisation domain-likesearch Potassium Channel Kv1.1; Chain Asearch PF03931: Skp1 family, tetramerisation domainsearch, PF01466: Skp1 family, dimerisation domainsearch

Chain ID Biological process (GO)
B, D, F, H, J, L, N, P (P63208) ubiquitin-dependent protein catabolic processsearch

Chain InterPro annotation
A, C, E, G, I, K, M, O F-box domainsearch
B, D, F, H, J, L, N, P S-phase kinase-associated protein 1-likesearch BTB/POZ foldsearch SKP1 component, dimerisationsearch SKP1 component, POZ domainsearch S-phase kinase-associated protein 1search