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Insights into scf ubiquitin ligases from the structure of the skp1-skp2 complex

X-ray diffraction
2.8Å resolution
PDB entry 1fqv coloured by chain, front view.
PDB entry 1fqv coloured by chain, side view.
PDB entry 1fqv coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: S-phase kinase-associated protein 2 and S-phase kinase-associated protein 1
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Multimeric state: hetero dimer
Accessible surface area: 20414.13 Å2
Buried surface area: 2977.47 Å2
Dissociation area: 1,488.73 Å2
Dissociation energy (ΔGdiss): 22.03 kcal/mol
Dissociation entropy (TΔSdiss): 12.51 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-159037
Assembly 2
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Assembly Name: S-phase kinase-associated protein 2 and S-phase kinase-associated protein 1
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Multimeric state: hetero dimer
Accessible surface area: 20496.45 Å2
Buried surface area: 2908.33 Å2
Dissociation area: 1,454.16 Å2
Dissociation energy (ΔGdiss): 22.57 kcal/mol
Dissociation entropy (TΔSdiss): 12.49 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-159037
Assembly 3
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Assembly Name: S-phase kinase-associated protein 2 and S-phase kinase-associated protein 1
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Multimeric state: hetero dimer
Accessible surface area: 20541.79 Å2
Buried surface area: 2890.06 Å2
Dissociation area: 1,445.03 Å2
Dissociation energy (ΔGdiss): 21.03 kcal/mol
Dissociation entropy (TΔSdiss): 12.49 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-159037
Assembly 4
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Assembly Name: S-phase kinase-associated protein 2 and S-phase kinase-associated protein 1
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Multimeric state: hetero dimer
Accessible surface area: 20472.05 Å2
Buried surface area: 2919.7 Å2
Dissociation area: 1,459.85 Å2
Dissociation energy (ΔGdiss): 21.94 kcal/mol
Dissociation entropy (TΔSdiss): 12.49 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-159037
Assembly 5
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Assembly Name: S-phase kinase-associated protein 2 and S-phase kinase-associated protein 1
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Multimeric state: hetero dimer
Accessible surface area: 20433.62 Å2
Buried surface area: 2934.52 Å2
Dissociation area: 1,467.26 Å2
Dissociation energy (ΔGdiss): 22.06 kcal/mol
Dissociation entropy (TΔSdiss): 12.5 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-159037
Assembly 6
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Assembly Name: S-phase kinase-associated protein 2 and S-phase kinase-associated protein 1
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Multimeric state: hetero dimer
Accessible surface area: 20526.74 Å2
Buried surface area: 2870.03 Å2
Dissociation area: 1,435.02 Å2
Dissociation energy (ΔGdiss): 21.47 kcal/mol
Dissociation entropy (TΔSdiss): 12.49 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-159037
Assembly 7
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Assembly Name: S-phase kinase-associated protein 2 and S-phase kinase-associated protein 1
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Multimeric state: hetero dimer
Accessible surface area: 20495.95 Å2
Buried surface area: 2941.45 Å2
Dissociation area: 1,470.73 Å2
Dissociation energy (ΔGdiss): 21.76 kcal/mol
Dissociation entropy (TΔSdiss): 12.5 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-159037
Assembly 8
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Assembly Name: S-phase kinase-associated protein 2 and S-phase kinase-associated protein 1
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Multimeric state: hetero dimer
Accessible surface area: 20414.84 Å2
Buried surface area: 2932.89 Å2
Dissociation area: 1,466.44 Å2
Dissociation energy (ΔGdiss): 22.65 kcal/mol
Dissociation entropy (TΔSdiss): 12.49 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-159037

Macromolecules

S-phase kinase-associated protein 2
Chains: A, C, E, G, I, K, M, O
Length: 336 amino acids
Theoretical weight: 37.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13309 (Residues: 89-424; Coverage: 79%)
Gene names: FBXL1, SKP2
Pfam: F-box-like
InterPro:
CATH: Ribonuclease Inhibitor
SCOP:
S-phase kinase-associated protein 2 in PDB entry 1fqv, assembly 1, front view.
S-phase kinase-associated protein 2 in PDB entry 1fqv, assembly 1, side view.
S-phase kinase-associated protein 2 in PDB entry 1fqv, assembly 1, top view.
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S-phase kinase-associated protein 1
Chains: B, D, F, H, J, L, N, P
Length: 149 amino acids
Theoretical weight: 16.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P63208 (Residues: 1-163; Coverage: 91%)
Gene names: EMC19, OCP2, SKP1, SKP1A, TCEB1L
Pfam:
InterPro:
CATH: Potassium Channel Kv1.1; Chain A
SCOP:
S-phase kinase-associated protein 1 in PDB entry 1fqv, assembly 1, front view.
S-phase kinase-associated protein 1 in PDB entry 1fqv, assembly 1, side view.
S-phase kinase-associated protein 1 in PDB entry 1fqv, assembly 1, top view.
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