1fqr Summary



The structure was published by Cox, J.D., Hunt, J.A., Compher, K.M., Fierke, C.A., and Christianson, D.W., in 2000 in a paper entitled "Structural influence of hydrophobic core residues on metal binding and specificity in carbonic anhydrase II." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2000.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 258 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) CARBONIC ANHYDRASE Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P00918) carbonate dehydratase activitysearch lyase activitysearch metal ion bindingsearch zinc ion bindingsearch protein bindingsearch secretionsearch positive regulation of cellular pH reductionsearch response to zinc ionsearch response to steroid hormonesearch positive regulation of osteoclast differentiationsearch positive regulation of bone resorptionsearch kidney developmentsearch response to pHsearch regulation of intracellular pHsearch regulation of chloride transportsearch positive regulation of dipeptide transmembrane transportsearch one-carbon metabolic processsearch regulation of anion transportsearch odontogenesis of dentin-containing toothsearch response to organic substancesearch morphogenesis of an epitheliumsearch response to estrogensearch bicarbonate transportsearch angiotensin-activated signaling pathwaysearch small molecule metabolic processsearch positive regulation of synaptic transmission, GABAergicsearch cytosolsearch extracellular vesicular exosomesearch basolateral plasma membranesearch cytoplasmsearch membranesearch extracellular spacesearch axonsearch plasma membranesearch apical part of cellsearch microvillussearch myelin sheathsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch