1fqk Summary

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CRYSTAL STRUCTURE OF THE HETERODIMERIC COMPLEX OF THE RGS DOMAIN OF RGS9, AND THE GT/I1 CHIMERA ALPHA SUBUNIT [(RGS9)-(GT/I1ALPHA)-(GDP)-(ALF4-)-(MG2+)]

The structure was published by Slep, K.C., Kercher, M.A., He, W., Cowan, C.W., Wensel, T.G., and Sigler, P.B., in 2001 in a paper entitled "Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2000.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely CHIMERA OF GUANINE NUCLEOTIDE-BINDING PROTEIN G(T), ALPHA-1 SUBUNIT AND GUANINE NUCLEOTIDE-BINDING PROTEIN G(I), ALPHA-1 SUBUNIT and REGULATOR OF G-PROTEIN SIGNALING 9.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CHIMERA OF GUANINE NUCLEOTIDE-BINDING PROTEIN G(T), ALPHA-1 SUBUNIT AND GUANINE NUCLEOTIDE-BINDING PROTEIN G(I), ALPHA-1 SUBUNIT P04695 (26-215) (GNAT1_BOVIN)search ,
P04695 (295-350) (GNAT1_BOVIN)search
Bos taurussearch ,
Bos taurussearch
93% ,
93%
325 97%
C CHIMERA OF GUANINE NUCLEOTIDE-BINDING PROTEIN G(T), ALPHA-1 SUBUNIT AND GUANINE NUCLEOTIDE-BINDING PROTEIN G(I), ALPHA-1 SUBUNIT P04695 (26-215) (GNAT1_BOVIN)search ,
P04695 (295-350) (GNAT1_BOVIN)search
Bos taurussearch ,
Bos taurussearch
93% ,
93%
325 97%
B REGULATOR OF G-PROTEIN SIGNALING 9 O46469 (276-422) (RGS9_BOVIN)search Bos taurussearch < 90% 147 97%
D REGULATOR OF G-PROTEIN SIGNALING 9 O46469 (276-422) (RGS9_BOVIN)search Bos taurussearch < 90% 147 97%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P04695 (26 - 215) CHIMERA OF GUANINE NUCLEOTIDE-BINDING PROTEIN G(T), ALPHA-1 SUBUNIT AND GUANINE NUCLEOTIDE-BINDING PROTEIN G(I), ALPHA-1 SUBUNIT Bos taurus, Rattus norvegicus
O46469 (276 - 422) REGULATOR OF G-PROTEIN SIGNALING 9 Bos taurus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P04695) Transducin (alpha subunit), insertion domainsearch, G proteinssearch P-loop containing nucleotide triphosphate hydrolasessearch, GI Alpha 1, domain 2-likesearch PF00503: G-protein alpha subunitsearch
B, D Regulator of G-protein signaling, RGSsearch Regulator of G-protein Signalling 4; domain 1search, Regulator of G-protein Signalling 4, domain 2search Regulator of G protein signaling domainsearch, GGL domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A, C (P04695) GTPase activitysearch GTP bindingsearch G-protein beta/gamma-subunit complex bindingsearch signal transducer activitysearch guanyl nucleotide bindingsearch G-protein coupled receptor signaling pathwaysearch adenylate cyclase-modulating G-protein coupled receptor signaling pathwaysearch GTP catabolic processsearch signal transductionsearch
B, D (O46469) termination of G-protein coupled receptor signaling pathwaysearch

Chain InterPro annotation
A, C Guanine nucleotide binding protein (G-protein), alpha subunitsearch G-protein alpha subunit, group Isearch G protein alpha subunit, helical insertionsearch P-loop containing nucleoside triphosphate hydrolasesearch
B, D Regulator of G protein signalling domainsearch Regulator of G protein signalling superfamilysearch Regulator of G-protein signalling, domain 1search