1fq1 Summary

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CRYSTAL STRUCTURE OF KINASE ASSOCIATED PHOSPHATASE (KAP) IN COMPLEX WITH PHOSPHO-CDK2

The structure was published by Song, H., Hanlon, N., Brown, N.R., Noble, M.E., Johnson, L.N., and Barford, D., in 2001 in a paper entitled "Phosphoprotein-protein interactions revealed by the crystal structure of kinase-associated phosphatase in complex with phosphoCDK2." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.0 Å and deposited in 2000.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely CYCLIN-DEPENDENT KINASE INHIBITOR 3 and CELL DIVISION PROTEIN KINASE 2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CYCLIN-DEPENDENT KINASE INHIBITOR 3 Q16667 (1-212) (CDKN3_HUMAN)search Homo sapienssearch 100% 212 86%
B CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 99%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q16667 (1 - 212) CYCLIN-DEPENDENT KINASE INHIBITOR 3 Homo sapiens
P24941 (1 - 298) CELL DIVISION PROTEIN KINASE 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q16667) Dual specificity phosphatase-likesearch Protein tyrosine phosphatase superfamilysearch PF05706: Cyclin-dependent kinase inhibitor 3 (CDKN3)search
B (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (Q16667) peptidyl-tyrosine dephosphorylationsearch dephosphorylationsearch cell cyclesearch cell cycle arrestsearch regulation of cyclin-dependent protein serine/threonine kinase activitysearch negative regulation of cell proliferationsearch G1/S transition of mitotic cell cyclesearch protein tyrosine/serine/threonine phosphatase activitysearch protein bindingsearch phosphoprotein phosphatase activitysearch phosphatase activitysearch protein tyrosine phosphatase activitysearch protein serine/threonine phosphatase activitysearch hydrolase activitysearch perinuclear region of cytoplasmsearch cytoplasmsearch
B (P24941) protein phosphorylationsearch cell cyclesearch positive regulation of transcription, DNA-templatedsearch G1/S transition of mitotic cell cyclesearch mitotic nuclear divisionsearch phosphorylationsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch mitotic cell cyclesearch mitotic G1 DNA damage checkpointsearch DNA replicationsearch positive regulation of cell proliferationsearch histone phosphorylationsearch cell divisionsearch regulation of gene silencingsearch DNA repairsearch Ras protein signal transductionsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch G2/M transition of mitotic cell cyclesearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch blood coagulationsearch potassium ion transportsearch meiotic nuclear divisionsearch cellular response to nitric oxidesearch cellular response to DNA damage stimulussearch centrosome duplicationsearch positive regulation of DNA-dependent DNA replication initiationsearch ATP bindingsearch protein serine/threonine kinase activitysearch protein kinase activitysearch cyclin bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch protein bindingsearch transferase activity, transferring phosphorus-containing groupssearch nucleotide bindingsearch transferase activitysearch metal ion bindingsearch kinase activitysearch histone kinase activitysearch nucleoplasmsearch cytosolsearch endosomesearch cytoplasmsearch Cajal bodysearch nucleussearch microtubule organizing centersearch centrosomesearch transcription factor complexsearch Y chromosomesearch condensed chromosomesearch chromosome, telomeric regionsearch cytoskeletonsearch cyclin-dependent protein kinase holoenzyme complexsearch X chromosomesearch

Chain InterPro annotation
A Protein-tyrosine/Dual specificity phosphatasesearch Cyclin-dependent kinase inhibitor 3search CDKN3 domainsearch Protein-tyrosine phosphatase-likesearch
B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch