1fos Summary

pdbe.org/1fos
spacer

TWO HUMAN C-FOS:C-JUN:DNA COMPLEXES

There is a Quite Interesting Protein Structure article for this entry.

The structure was published by Glover, J.N. and Harrison, S.C., in 1995 in a paper entitled "Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.05 Å and deposited in 1995.

The experimental data on which the structure is based was not deposited.

This entry contains 8 copies of 4 unique biopolymers (complete list).

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
E P55-C-FOS PROTO-ONCOGENE PROTEIN P01100 (139-200) (FOS_HUMAN)search Homo sapienssearch < 90% 62 96%
G P55-C-FOS PROTO-ONCOGENE PROTEIN P01100 (139-200) (FOS_HUMAN)search Homo sapienssearch < 90% 62 96%
F C-JUN PROTO-ONCOGENE PROTEIN P05412 (254-315) (JUN_HUMAN)search Homo sapienssearch < 90% 62 93%
H C-JUN PROTO-ONCOGENE PROTEIN P05412 (254-315) (JUN_HUMAN)search Homo sapienssearch < 90% 62 93%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P01100 (139 - 200) P55-C-FOS PROTO-ONCOGENE PROTEIN Homo sapiens
P05412 (254 - 315) C-JUN PROTO-ONCOGENE PROTEIN Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
E, G Leucine zipper domainsearch Single alpha-helices involved in coiled-coils or other helix-helix interfacessearch bZIP transcription factorsearch
F, H Leucine zipper domainsearch Single alpha-helices involved in coiled-coils or other helix-helix interfacessearch bZIP transcription factorsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
E, G (P01100) DNA bindingsearch sequence-specific DNA binding transcription factor activitysearch sequence-specific DNA bindingsearch nucleussearch regulation of transcription, DNA-templatedsearch
F, H (P05412) DNA bindingsearch sequence-specific DNA binding transcription factor activitysearch sequence-specific DNA bindingsearch nucleussearch regulation of transcription, DNA-templatedsearch

Chain InterPro annotation
E, G AP-1 transcription factorsearch Basic-leucine zipper domainsearch
F, H Transcription factor Junsearch Basic-leucine zipper domainsearch Transcription factor, Skn-1-like, DNA-binding domainsearch