1fn3 Summary

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CRYSTAL STRUCTURE OF NICKEL RECONSTITUTED HEMOGLOBIN-A CASE FOR PERMANENT, T-STATE HEMOGLOBIN

The structure was published by Venkateshrao, S., Deepthi, S., Pattabhi, V., and Manoharan, P.T., in 2003 in a paper entitled "Crystal Structure of Nickel Reconstituted Hemoglobin - A Case for Permanent, T-State Hemoglobin" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.48 Å and deposited in 2000.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN ALPHA CHAIN and HEMOGLOBIN BETA CHAIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN ALPHA CHAIN P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN ALPHA CHAIN P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN BETA CHAIN P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN BETA CHAIN P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN ALPHA CHAIN Homo sapiens
P68871 (2 - 147) HEMOGLOBIN BETA CHAIN Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, C (P69905) heme bindingsearch iron ion bindingsearch oxygen bindingsearch protein bindingsearch haptoglobin bindingsearch metal ion bindingsearch peroxidase activitysearch oxygen transporter activitysearch hemoglobin complexsearch extracellular vesicular exosomesearch cytosolsearch membranesearch extracellular regionsearch blood microparticlesearch cytosolic small ribosomal subunitsearch haptoglobin-hemoglobin complexsearch endocytic vesicle lumensearch oxygen transportsearch bicarbonate transportsearch protein heterooligomerizationsearch transportsearch response to hydrogen peroxidesearch positive regulation of cell deathsearch small molecule metabolic processsearch hydrogen peroxide catabolic processsearch oxidation-reduction processsearch
B, D (P68871) heme bindingsearch oxygen bindingsearch metal ion bindingsearch protein bindingsearch iron ion bindingsearch hemoglobin bindingsearch oxygen transporter activitysearch haptoglobin bindingsearch peroxidase activitysearch hemoglobin complexsearch extracellular regionsearch extracellular vesicular exosomesearch haptoglobin-hemoglobin complexsearch endocytic vesicle lumensearch cytosolsearch blood microparticlesearch oxygen transportsearch renal absorptionsearch regulation of blood vessel sizesearch nitric oxide transportsearch response to hydrogen peroxidesearch blood coagulationsearch bicarbonate transportsearch regulation of blood pressuresearch positive regulation of cell deathsearch transportsearch positive regulation of nitric oxide biosynthetic processsearch small molecule metabolic processsearch protein heterooligomerizationsearch oxidation-reduction processsearch hydrogen peroxide catabolic processsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch