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EBI PDBe PDBeView

PDBe Entry: 1fmi view

CRYSTAL STRUCTURE OF HUMAN CLASS I ALPHA1,2-MANNOSIDASE
Summary
Header HYDROLASEsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 1.9 Å, R-factor: 22.2%, Free R-factor: 25.0%, Spacegroup: P 31 2 1
Released 17/01/2001, deposition: 17/08/2000, last revision: 24/02/2009
Authors Vallee, F.search; Karaveg, K.search; Herscovics, A.search; Moremen, K.W.search; Howell, P.L.search
Primary citation Structural basis for catalysis and inhibition of N-glycan processing class I alpha 1,2-mannosidases.
J.BIOL.CHEM.search vol:275, pag:41287-41298 (2000) [PubMed ID 10995765 ]search
Keywords alpha-alpha7 barrelsearch, HYDROLASEsearch
EC 3.2.1.113 ExPASy BRENDA search (A)
Organism Homo sapiens(human) 9606search(A)
UniProt Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (EC 3.2.1.113) (ER alpha-1,2-mannosidase) (Mannosidase alpha class 1B member 1) (Man9GlcNAc2-specific-processing alpha-mannosidase) Q9UKM7search (A)
Solvent A
Polymers
Id Name Type UniProt Residues Observed
A ENDOPLASMIC RETICULUM ALPHA-MANNOSIDASE I Protein Q9UKM7 (MA1B1_HUMAN)search
 458 99%
Heterogens
Id Name Ligands
A CALCIUM ION CA search
A SULFATE ION SO4 search
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