1fm9 Summary

pdbe.org/1fm9
spacer

THE 2.1 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF THE HETERODIMER OF THE HUMAN RXRALPHA AND PPARGAMMA LIGAND BINDING DOMAINS RESPECTIVELY BOUND WITH 9-CIS RETINOIC ACID AND GI262570 AND CO-ACTIVATOR PEPTIDES.

The structure was published by Gampe Jr., R.T., Montana, V.G., Lambert, M.H., et al., Kliewer, S.A., Willson, T.M., and Xu, H.E., in 2000 in a paper entitled "Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2000.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely RETINOIC ACID RECEPTOR RXR-ALPHA, PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA, and STEROID RECEPTOR COACTIVATOR.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A RETINOIC ACID RECEPTOR RXR-ALPHA P19793 (225-462) (RXRA_HUMAN)search Homo sapienssearch 98% 238 97%
D PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA P37231 (234-505) (PPARG_HUMAN)search Homo sapienssearch < 90% 272 100%
B STEROID RECEPTOR COACTIVATOR Q15788 (676-700) (NCOA1_HUMAN)search Homo sapienssearch < 90% 25 64%
E STEROID RECEPTOR COACTIVATOR Q15788 (676-700) (NCOA1_HUMAN)search Homo sapienssearch < 90% 25 64%


This entry contains 3 unique UniProt proteins:

UniProt accession Name Organism PDB
P19793 (225 - 462) RETINOIC ACID RECEPTOR RXR-ALPHA Homo sapiens
P37231 (234 - 505) PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA Homo sapiens
Q15788 (676 - 700) STEROID RECEPTOR COACTIVATOR

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P19793) Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch PF00104: Ligand-binding domain of nuclear hormone receptorsearch
D Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch
B, E Steroid receptor coactivatorsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P19793) steroid hormone receptor activitysearch zinc ion bindingsearch sequence-specific DNA binding transcription factor activitysearch DNA bindingsearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch nucleussearch
D (P37231) steroid hormone receptor activitysearch sequence-specific DNA binding transcription factor activitysearch DNA bindingsearch ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activitysearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch nucleussearch

Chain InterPro annotation
A Retinoid X receptor/HNF4search Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch
D Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Peroxisome proliferator-activated receptorsearch Nuclear hormone receptor, ligand-bindingsearch
B, E Nuclear receptor coactivator Src-1search Steroid receptor coactivatorsearch Nuclear receptor coactivatorsearch Nuclear receptor coactivator 1search