1fkn Summary

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Structure of Beta-Secretase Complexed with Inhibitor

The structure was published by Hong, L., Koelsch, G., Lin, X., et al., Ghosh, A.K., Zhang, X.C., and Tang, J., in 2000 in a paper entitled "Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2000.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely MEMAPSIN 2 and inhibitor.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A MEMAPSIN 2 P56817 (56-446) (BACE1_HUMAN)search Homo sapienssearch < 90% 391 100%
B MEMAPSIN 2 P56817 (56-446) (BACE1_HUMAN)search Homo sapienssearch < 90% 391 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P56817 (56 - 446) MEMAPSIN 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Pepsin-likesearch Acid Proteasessearch Eukaryotic aspartyl proteasesearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (P56817) aspartic-type endopeptidase activitysearch proteolysissearch

Chain InterPro annotation
A, B Aspartic peptidasesearch Aspartic peptidase, active sitesearch Peptidase A1, beta-site APP cleaving enzyme, BACEsearch Peptidase A1, beta-site APP cleaving enzyme 1, BACE 1search Aspartic peptidase domainsearch