1fkd Summary

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FK-506 BINDING PROTEIN: THREE-DIMENSIONAL STRUCTURE OF THE COMPLEX WITH THE ANTAGONIST L-685,818

The structure was published by Becker, J.W., Rotonda, J., McKeever, B.M., et al., Wiederrecht, G., Hermes, J.D., and Springer, J.P., in 1993 in a paper entitled "FK-506-binding protein: three-dimensional structure of the complex with the antagonist L-685,818." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.72 Å and deposited in 1992.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of FK506 BINDING PROTEIN. This molecule has the UniProt identifier P62942 (FKB1A_HUMAN)search. The sample contained 107 residues which is 99% of the natural sequence. Out of 107 residues 107 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A FK506 BINDING PROTEIN P62942 (2-108) (FKB1A_HUMAN)search Homo sapienssearch 99% 107 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P62942 (2 - 108) FK506 BINDING PROTEIN Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P62942) FKBP immunophilin/proline isomerasesearch Chitinase A; domain 3search PF00254: FKBP-type peptidyl-prolyl cis-trans isomerasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P62942) calcium channel inhibitor activitysearch peptidyl-prolyl cis-trans isomerase activitysearch signal transducer activitysearch transforming growth factor beta receptor bindingsearch protein bindingsearch macrolide bindingsearch FK506 bindingsearch drug bindingsearch isomerase activitysearch enzyme bindingsearch Hsp70 protein bindingsearch type I transforming growth factor beta receptor bindingsearch protein homodimerization activitysearch ion channel bindingsearch SMAD bindingsearch activin bindingsearch negative regulation of release of sequestered calcium ion into cytosolsearch negative regulation of ryanodine-sensitive calcium-release channel activitysearch protein peptidyl-prolyl isomerizationsearch negative regulation of protein phosphorylationsearch heart morphogenesissearch protein foldingsearch 'de novo' protein foldingsearch muscle contractionsearch transforming growth factor beta receptor signaling pathwaysearch SMAD protein complex assemblysearch response to iron ionsearch cytokine-mediated signaling pathwaysearch protein maturation by protein foldingsearch response to caffeinesearch positive regulation of protein ubiquitinationsearch positive regulation of protein bindingsearch negative regulation of protein phosphatase type 2B activitysearch regulation of protein localizationsearch regulation of activin receptor signaling pathwaysearch protein refoldingsearch T cell proliferationsearch T cell activationsearch positive regulation of I-kappaB kinase/NF-kappaB signalingsearch extracellular fibril organizationsearch regulation of immune responsesearch release of sequestered calcium ion into cytosolsearch ventricular cardiac muscle tissue morphogenesissearch regulation of ryanodine-sensitive calcium-release channel activitysearch heart trabecula formationsearch chaperone-mediated protein foldingsearch calcium ion transmembrane transportsearch regulation of amyloid precursor protein catabolic processsearch amyloid fibril formationsearch cytoplasmsearch endoplasmic reticulum membranesearch cytosolsearch terminal cisternasearch membranesearch Z discsearch sarcoplasmic reticulum membranesearch intracellular membrane-bounded organellesearch axon terminussearch extracellular vesicular exosomesearch

Chain InterPro annotation
A Peptidyl-prolyl cis-trans isomerase, FKBP-type, domainsearch Peptidyl-prolyl cis-trans isomerase, FKBP-typesearch