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FK-506 BINDING PROTEIN: THREE-DIMENSIONAL STRUCTURE OF THE COMPLEX WITH THE ANTAGONIST L-685,818

X-ray diffraction
1.72Å resolution
PDB entry 1fkd coloured by chain, front view.
PDB entry 1fkd coloured by chain, side view.
PDB entry 1fkd coloured by chain, top view.
Source organism: Homo sapiens
Assemblies composition:
homo dimer (preferred)
homo tetramer
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Peptidyl-prolyl cis-trans isomerase FKBP1A
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Multimeric state: homo dimer
Accessible surface area: 10448.96 Å2
Buried surface area: 3473.19 Å2
Dissociation area: 891.06 Å2
Dissociation energy (ΔGdiss): 1.7 kcal/mol
Dissociation entropy (TΔSdiss): 11.19 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-158814
Assembly 2
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Assembly Name: Peptidyl-prolyl cis-trans isomerase FKBP1A
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Multimeric state: homo tetramer
Accessible surface area: 18211.98 Å2
Buried surface area: 9629.66 Å2
Dissociation area: 3,127 Å2
Dissociation energy (ΔGdiss): 17.45 kcal/mol
Dissociation entropy (TΔSdiss): 35.27 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-158816

Macromolecules

Peptidyl-prolyl cis-trans isomerase FKBP1A
Chain: A
Length: 107 amino acids
Theoretical weight: 11.84 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P62942 (Residues: 2-108; Coverage: 99%)
Gene names: FKBP1, FKBP12, FKBP1A
Pfam: FKBP-type peptidyl-prolyl cis-trans isomerase
InterPro:
CATH: Chitinase A; domain 3
SCOP: FKBP immunophilin/proline isomerase
Peptidyl-prolyl cis-trans isomerase FKBP1A in PDB entry 1fkd, assembly 1, front view.
Peptidyl-prolyl cis-trans isomerase FKBP1A in PDB entry 1fkd, assembly 1, side view.
Peptidyl-prolyl cis-trans isomerase FKBP1A in PDB entry 1fkd, assembly 1, top view.
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