1fiq Summary



The structure was published by Enroth, C., Eger, B.T., Okamoto, K., Nishino, T., Nishino, T., and Pai, E.F., in 2000 in a paper entitled "Crystal structures of bovine milk xanthine dehydrogenase and xanthine oxidase: structure-based mechanism of conversion." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2000.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely XANTHINE OXIDASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterohexamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A XANTHINE OXIDASE P80457 (1-219) (XDH_BOVIN)search Bos taurussearch 100% 219 74%
B XANTHINE OXIDASE P80457 (220-569) (XDH_BOVIN)search Bos taurussearch 100% 350 87%
C XANTHINE OXIDASE P80457 (570-1332) (XDH_BOVIN)search Bos taurussearch 100% 763 97%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P80457 (1 - 219) XANTHINE OXIDASE Bos taurus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P80457) CO dehydrogenase ISP C-domain likesearch, 2Fe-2S ferredoxin domains from multidomain proteinssearch Ubiquitin-like (UB roll)search, DNA polymerase; domain 1search PF00111: 2Fe-2S iron-sulfur cluster binding domainsearch, PF01799: [2Fe-2S] binding domainsearch
B (P80457) CO dehydrogenase flavoprotein C-terminal domain-likesearch, CO dehydrogenase flavoprotein N-terminal domain-likesearch Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2search, Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3search, Enolase-like; domain 1search PF00941: FAD binding domain in molybdopterin dehydrogenasesearch, PF03450: CO dehydrogenase flavoprotein C-terminal domainsearch
C (P80457) CO dehydrogenase molybdoprotein N-domain-likesearch, Molybdenum cofactor-binding domainsearch Aldehyde Oxidoreductase; domain 3search, Aldehyde Oxidoreductase; domain 4search PF01315: Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domainsearch, PF02738: Molybdopterin-binding domain of aldehyde dehydrogenasesearch

Chain ID Molecular function (GO) Biological process (GO)
A (P80457) electron carrier activitysearch iron-sulfur cluster bindingsearch oxidoreductase activitysearch 2 iron, 2 sulfur cluster bindingsearch metal ion bindingsearch oxidation-reduction processsearch
B (P80457) catalytic activitysearch UDP-N-acetylmuramate dehydrogenase activitysearch flavin adenine dinucleotide bindingsearch oxidoreductase activity, acting on CH-OH group of donorssearch oxidoreductase activitysearch oxidation-reduction processsearch
C (P80457) molybdopterin cofactor bindingsearch oxidoreductase activitysearch oxidation-reduction processsearch

Chain InterPro annotation
A 2Fe-2S ferredoxin-type domainsearch [2Fe-2S]-bindingsearch 2Fe-2S ferredoxin, iron-sulphur binding sitesearch Beta-grasp domainsearch
B Molybdopterin dehydrogenase, FAD-bindingsearch CO dehydrogenase flavoprotein, C-terminalsearch FAD-binding, type 2search FAD-binding, type 2, subdomain 1search CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2search
C Aldehyde oxidase/xanthine dehydrogenase, a/b hammerheadsearch Aldehyde oxidase/xanthine dehydrogenase, molybdopterin bindingsearch Oxidoreductase, molybdopterin binding sitesearch