1fiq Summary

pdbe.org/1fiq
spacer

CRYSTAL STRUCTURE OF XANTHINE OXIDASE FROM BOVINE MILK

The structure was published by Enroth, C., Eger, B.T., Okamoto, K., Nishino, T., Nishino, T., and Pai, E.F., in 2000 in a paper entitled "Crystal structures of bovine milk xanthine dehydrogenase and xanthine oxidase: structure-based mechanism of conversion." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2000.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely XANTHINE OXIDASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterohexamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A XANTHINE OXIDASE P80457 (1-219) (XDH_BOVIN)search Bos taurussearch 100% 219 74%
B XANTHINE OXIDASE P80457 (220-569) (XDH_BOVIN)search Bos taurussearch 100% 350 87%
C XANTHINE OXIDASE P80457 (570-1332) (XDH_BOVIN)search Bos taurussearch 100% 763 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P80457 (1 - 219) XANTHINE OXIDASE Bos taurus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P80457) CO dehydrogenase ISP C-domain likesearch, 2Fe-2S ferredoxin domains from multidomain proteinssearch Ubiquitin-like (UB roll)search, DNA polymerase; domain 1search PF00111: 2Fe-2S iron-sulfur cluster binding domainsearch, PF01799: [2Fe-2S] binding domainsearch
B (P80457) CO dehydrogenase flavoprotein C-terminal domain-likesearch, CO dehydrogenase flavoprotein N-terminal domain-likesearch Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2search, Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3search, Enolase-like; domain 1search PF00941: FAD binding domain in molybdopterin dehydrogenasesearch, PF03450: CO dehydrogenase flavoprotein C-terminal domainsearch
C (P80457) CO dehydrogenase molybdoprotein N-domain-likesearch, Molybdenum cofactor-binding domainsearch Aldehyde Oxidoreductase; domain 3search, Aldehyde Oxidoreductase; domain 4search PF01315: Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domainsearch, PF02738: Molybdopterin-binding domain of aldehyde dehydrogenasesearch

Chain ID Molecular function (GO) Biological process (GO)
A (P80457) oxidoreductase activitysearch iron-sulfur cluster bindingsearch 2 iron, 2 sulfur cluster bindingsearch electron carrier activitysearch metal ion bindingsearch oxidation-reduction processsearch
B (P80457) catalytic activitysearch oxidoreductase activity, acting on CH-OH group of donorssearch flavin adenine dinucleotide bindingsearch oxidoreductase activitysearch UDP-N-acetylmuramate dehydrogenase activitysearch oxidation-reduction processsearch
C (P80457) molybdopterin cofactor bindingsearch oxidoreductase activitysearch oxidation-reduction processsearch

Chain InterPro annotation
A 2Fe-2S ferredoxin-type domainsearch [2Fe-2S]-bindingsearch 2Fe-2S ferredoxin, iron-sulphur binding sitesearch Beta-grasp domainsearch
B Molybdopterin dehydrogenase, FAD-bindingsearch CO dehydrogenase flavoprotein, C-terminalsearch FAD-binding, type 2search FAD-binding, type 2, subdomain 1search CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2search
C Aldehyde oxidase/xanthine dehydrogenase, a/b hammerheadsearch Aldehyde oxidase/xanthine dehydrogenase, molybdopterin bindingsearch Oxidoreductase, molybdopterin binding sitesearch