1fgk Summary

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CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FIBROBLAST GROWTH FACTOR RECEPTOR 1

The structure was published by Mohammadi, M., Schlessinger, J., and Hubbard, S.R., in 1996 in a paper entitled "Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 1997.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of FGF RECEPTOR 1.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A FGF RECEPTOR 1 P11362 (456-765) (FGFR1_HUMAN)search Homo sapienssearch < 90% 310 89%
B FGF RECEPTOR 1 P11362 (456-765) (FGFR1_HUMAN)search Homo sapienssearch < 90% 310 89%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P11362 (456 - 765) FGF RECEPTOR 1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (P11362) transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein kinase activitysearch fibroblast growth factor-activated receptor activitysearch protein tyrosine kinase activitysearch protein phosphorylationsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch Fibroblast growth factor receptor 1/4search