1fgi Summary

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CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FIBROBLAST GROWTH FACTOR RECEPTOR 1 IN COMPLEX WITH SU5402 INHIBITOR

The structure was published by Mohammadi, M., McMahon, G., Sun, L., et al., Yeh, B.K., Hubbard, S.R., and Schlessinger, J., in 1997 in a paper entitled "Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 1997.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of FGF RECEPTOR 1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A FGF RECEPTOR 1 P11362 (456-765) (FGFR1_HUMAN)search Homo sapienssearch < 90% 310 91%
B FGF RECEPTOR 1 P11362 (456-765) (FGFR1_HUMAN)search Homo sapienssearch < 90% 310 91%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P11362 (456 - 765) FGF RECEPTOR 1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (P11362) protein kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein tyrosine kinase activitysearch fibroblast growth factor-activated receptor activitysearch protein phosphorylationsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch Fibroblast growth factor receptor 1/4search