1fg9 Summary

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3:1 COMPLEX OF INTERFERON-GAMMA RECEPTOR WITH INTERFERON-GAMMA DIMER

The structure was published by Thiel, D.J., le Du, M.H., Walter, R.L., et al., Garotta, G., Winkler, F.K., and Ealick, S.E., in 2000 in a paper entitled "Observation of an unexpected third receptor molecule in the crystal structure of human interferon-gamma receptor complex." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2000.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely INTERFERON GAMMA and INTERFERON-GAMMA RECEPTOR ALPHA CHAIN.

The molecule most likely forms heteropentamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A INTERFERON GAMMA P01579 (24-156) (IFNG_HUMAN)search Homo sapienssearch 90% 134 94%
B INTERFERON GAMMA P01579 (24-156) (IFNG_HUMAN)search Homo sapienssearch 90% 134 94%
C INTERFERON-GAMMA RECEPTOR ALPHA CHAIN P15260 (18-262) (INGR1_HUMAN)search Homo sapienssearch < 90% 245 85%
D INTERFERON-GAMMA RECEPTOR ALPHA CHAIN P15260 (18-262) (INGR1_HUMAN)search Homo sapienssearch < 90% 245 85%
E INTERFERON-GAMMA RECEPTOR ALPHA CHAIN P15260 (18-262) (INGR1_HUMAN)search Homo sapienssearch < 90% 245 85%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P01579 (24 - 156) INTERFERON GAMMA Homo sapiens
P15260 (18 - 262) INTERFERON-GAMMA RECEPTOR ALPHA CHAIN Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P01579) Interferons/interleukin-10 (IL-10)search Growth Hormone; Chain: A;search PF00714: Interferon gammasearch
C, D, E Fibronectin type IIIsearch Immunoglobulinssearch Tissue factorsearch, Interferon gamma receptor (IFNGR1)search

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, B (P01579) negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesissearch regulation of neuronal action potentialsearch adaptive immune responsesearch positive regulation of nitric oxide biosynthetic processsearch sensory perception of mechanical stimulussearch positive regulation of fructose 1,6-bisphosphate 1-phosphatase activitysearch response to virussearch defense response to virussearch neutrophil chemotaxissearch positive regulation of osteoclast differentiationsearch neutrophil apoptotic processsearch positive regulation of isotype switching to IgG isotypessearch regulation of transcription, DNA-templatedsearch positive regulation of peptidyl-serine phosphorylation of STAT proteinsearch positive regulation of interleukin-6 biosynthetic processsearch positive regulation of mesenchymal cell proliferationsearch defense response to bacteriumsearch inflammatory cell apoptotic processsearch positive regulation of tumor necrosis factor (ligand) superfamily member 11 productionsearch cell surface receptor signaling pathwaysearch negative regulation of cell proliferationsearch extrinsic apoptotic signaling pathwaysearch negative regulation of metanephric nephron tubule epithelial cell differentiationsearch defense response to protozoansearch positive regulation of interleukin-23 productionsearch positive regulation of neuron differentiationsearch regulation of interferon-gamma-mediated signaling pathwaysearch interferon-gamma-mediated signaling pathwaysearch negative regulation of growth of symbiont involved in interaction with hostsearch positive regulation of interleukin-12 productionsearch regulation of growthsearch negative regulation of transcription from RNA polymerase II promotersearch positive regulation of tumor necrosis factor productionsearch positive regulation of transcription, DNA-templatedsearch positive regulation of MHC class II biosynthetic processsearch humoral immune responsesearch regulation of hepatocyte proliferationsearch endoplasmic reticulum unfolded protein responsesearch positive regulation of fructose 1,6-bisphosphate metabolic processsearch positive regulation of interleukin-12 biosynthetic processsearch CD8-positive, alpha-beta T cell differentiation involved in immune responsesearch cell cycle arrestsearch cellular response to lipopolysaccharidesearch regulation of the force of heart contractionsearch positive regulation of transcription from RNA polymerase II promotersearch cellular response to interleukin-18search negative regulation of myelinationsearch regulation of immune responsesearch apoptotic processsearch positive regulation of cell adhesionsearch negative regulation of interleukin-17 productionsearch positive regulation of killing of cells of other organismsearch positive regulation of membrane protein ectodomain proteolysissearch positive regulation of synaptic transmission, cholinergicsearch negative regulation of smooth muscle cell proliferationsearch response to drugsearch negative regulation of growth of symbiont in hostsearch immune responsesearch protein import into nucleus, translocationsearch positive regulation of cell proliferationsearch positive regulation of tyrosine phosphorylation of Stat1 proteinsearch antigen processing and presentationsearch positive regulation of calcidiol 1-monooxygenase activitysearch positive regulation of chemokine biosynthetic processsearch negative regulation of epithelial cell differentiationsearch regulation of insulin secretionsearch positive regulation of interleukin-1 beta secretionsearch positive regulation of T cell proliferationsearch movement of cell or subcellular componentsearch cytokine-mediated signaling pathwaysearch positive regulation of smooth muscle cell apoptotic processsearch positive regulation of vitamin D biosynthetic processsearch extracellular regionsearch extracellular spacesearch external side of plasma membranesearch cytokine activitysearch interferon-gamma receptor bindingsearch
C, D, E (P15260) membranesearch cytokine bindingsearch

Chain InterPro annotation
A, B Interferon gammasearch Four-helical cytokine-like, coresearch Four-helical cytokine, coresearch
C, D, E Fibronectin type IIIsearch Interferon gamma receptor alpha subunitsearch Immunoglobulin-like foldsearch Interferon gamma receptor, poxvirus/mammalsearch