1fg9 Summary

pdbe.org/1fg9
spacer

3:1 COMPLEX OF INTERFERON-GAMMA RECEPTOR WITH INTERFERON-GAMMA DIMER

The structure was published by Thiel, D.J., le Du, M.H., Walter, R.L., et al., Garotta, G., Winkler, F.K., and Ealick, S.E., in 2000 in a paper entitled "Observation of an unexpected third receptor molecule in the crystal structure of human interferon-gamma receptor complex." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2000.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely INTERFERON GAMMA and INTERFERON-GAMMA RECEPTOR ALPHA CHAIN.

The molecule most likely forms heteropentamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A INTERFERON GAMMA P01579 (24-156) (IFNG_HUMAN)search Homo sapienssearch 90% 134 94%
B INTERFERON GAMMA P01579 (24-156) (IFNG_HUMAN)search Homo sapienssearch 90% 134 94%
C INTERFERON-GAMMA RECEPTOR ALPHA CHAIN P15260 (18-262) (INGR1_HUMAN)search Homo sapienssearch < 90% 245 85%
D INTERFERON-GAMMA RECEPTOR ALPHA CHAIN P15260 (18-262) (INGR1_HUMAN)search Homo sapienssearch < 90% 245 85%
E INTERFERON-GAMMA RECEPTOR ALPHA CHAIN P15260 (18-262) (INGR1_HUMAN)search Homo sapienssearch < 90% 245 85%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P01579 (24 - 156) INTERFERON GAMMA Homo sapiens
P15260 (18 - 262) INTERFERON-GAMMA RECEPTOR ALPHA CHAIN Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P01579) Interferons/interleukin-10 (IL-10)search Growth Hormone; Chain: A;search PF00714: Interferon gammasearch
C, D, E Fibronectin type IIIsearch Immunoglobulinssearch Tissue factorsearch, Interferon gamma receptor (IFNGR1)search

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B (P01579) interferon-gamma receptor bindingsearch cytokine activitysearch extracellular regionsearch extracellular spacesearch external side of plasma membranesearch positive regulation of cell adhesionsearch positive regulation of chemokine biosynthetic processsearch apoptotic processsearch negative regulation of growth of symbiont in hostsearch positive regulation of peptidyl-serine phosphorylation of STAT proteinsearch negative regulation of myelinationsearch positive regulation of interleukin-12 productionsearch negative regulation of interleukin-17 productionsearch positive regulation of killing of cells of other organismsearch positive regulation of interleukin-1 beta secretionsearch neutrophil apoptotic processsearch positive regulation of membrane protein ectodomain proteolysissearch negative regulation of growth of symbiont involved in interaction with hostsearch cellular response to lipopolysaccharidesearch positive regulation of synaptic transmission, cholinergicsearch positive regulation of interleukin-12 biosynthetic processsearch neutrophil chemotaxissearch positive regulation of nitric oxide biosynthetic processsearch negative regulation of smooth muscle cell proliferationsearch inflammatory cell apoptotic processsearch negative regulation of cell proliferationsearch positive regulation of MHC class II biosynthetic processsearch positive regulation of transcription, DNA-templatedsearch cell cycle arrestsearch adaptive immune responsesearch regulation of the force of heart contractionsearch defense response to virussearch cytokine-mediated signaling pathwaysearch antigen processing and presentationsearch endoplasmic reticulum unfolded protein responsesearch positive regulation of neuron differentiationsearch negative regulation of transcription from RNA polymerase II promotersearch humoral immune responsesearch defense response to protozoansearch positive regulation of calcidiol 1-monooxygenase activitysearch positive regulation of tyrosine phosphorylation of Stat1 proteinsearch negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesissearch positive regulation of T cell proliferationsearch positive regulation of mesenchymal cell proliferationsearch regulation of insulin secretionsearch positive regulation of isotype switching to IgG isotypessearch immune responsesearch cellular response to interleukin-18search protein import into nucleus, translocationsearch interferon-gamma-mediated signaling pathwaysearch CD8-positive, alpha-beta T cell differentiation involved in immune responsesearch response to drugsearch negative regulation of metanephric nephron tubule epithelial cell differentiationsearch regulation of growthsearch positive regulation of smooth muscle cell apoptotic processsearch positive regulation of vitamin D biosynthetic processsearch regulation of transcription, DNA-templatedsearch regulation of immune responsesearch positive regulation of fructose 1,6-bisphosphate 1-phosphatase activitysearch defense response to bacteriumsearch response to virussearch cellular component movementsearch positive regulation of osteoclast differentiationsearch positive regulation of fructose 1,6-bisphosphate metabolic processsearch positive regulation of transcription from RNA polymerase II promotersearch positive regulation of interleukin-6 biosynthetic processsearch cell surface receptor signaling pathwaysearch extrinsic apoptotic signaling pathwaysearch positive regulation of tumor necrosis factor (ligand) superfamily member 11 productionsearch positive regulation of tumor necrosis factor productionsearch positive regulation of interleukin-23 productionsearch regulation of interferon-gamma-mediated signaling pathwaysearch
C, D, E (P15260) cytokine bindingsearch membranesearch

Chain InterPro annotation
A, B Interferon gammasearch Four-helical cytokine-like, coresearch Four-helical cytokine, coresearch
C, D, E Fibronectin, type IIIsearch Interferon gamma receptor alpha subunitsearch Immunoglobulin-like foldsearch Interferon gamma receptor, poxvirus/mammalsearch