1fg9 Summary

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3:1 COMPLEX OF INTERFERON-GAMMA RECEPTOR WITH INTERFERON-GAMMA DIMER

The structure was published by Thiel, D.J., le Du, M.H., Walter, R.L., et al., Garotta, G., Winkler, F.K., and Ealick, S.E., in 2000 in a paper entitled "Observation of an unexpected third receptor molecule in the crystal structure of human interferon-gamma receptor complex." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2000.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely INTERFERON GAMMA and INTERFERON-GAMMA RECEPTOR ALPHA CHAIN.

The molecule most likely forms heteropentamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A INTERFERON GAMMA P01579 (24-156) (IFNG_HUMAN)search Homo sapienssearch 90% 134 94%
B INTERFERON GAMMA P01579 (24-156) (IFNG_HUMAN)search Homo sapienssearch 90% 134 94%
C INTERFERON-GAMMA RECEPTOR ALPHA CHAIN P15260 (18-262) (INGR1_HUMAN)search Homo sapienssearch < 90% 245 85%
D INTERFERON-GAMMA RECEPTOR ALPHA CHAIN P15260 (18-262) (INGR1_HUMAN)search Homo sapienssearch < 90% 245 85%
E INTERFERON-GAMMA RECEPTOR ALPHA CHAIN P15260 (18-262) (INGR1_HUMAN)search Homo sapienssearch < 90% 245 85%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P01579 (24 - 156) INTERFERON GAMMA Homo sapiens
P15260 (18 - 262) INTERFERON-GAMMA RECEPTOR ALPHA CHAIN Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P01579) Interferons/interleukin-10 (IL-10)search Growth Hormone; Chain: A;search PF00714: Interferon gammasearch
C, D, E Fibronectin type IIIsearch Immunoglobulinssearch Tissue factorsearch, Interferon gamma receptor (IFNGR1)search

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, B (P01579) extracellular regionsearch external side of plasma membranesearch extracellular spacesearch positive regulation of interleukin-12 productionsearch negative regulation of transcription from RNA polymerase II promotersearch positive regulation of cell adhesionsearch negative regulation of myelinationsearch defense response to virussearch extrinsic apoptotic signaling pathwaysearch adaptive immune responsesearch positive regulation of T cell proliferationsearch positive regulation of transcription, DNA-templatedsearch positive regulation of tumor necrosis factor (ligand) superfamily member 11 productionsearch defense response to bacteriumsearch cell surface receptor signaling pathwaysearch negative regulation of cell proliferationsearch negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesissearch regulation of immune responsesearch negative regulation of metanephric nephron tubule epithelial cell differentiationsearch antigen processing and presentationsearch positive regulation of fructose 1,6-bisphosphate metabolic processsearch neutrophil apoptotic processsearch positive regulation of chemokine biosynthetic processsearch immune responsesearch positive regulation of peptidyl-serine phosphorylation of STAT proteinsearch apoptotic processsearch positive regulation of neuron differentiationsearch defense response to protozoansearch inflammatory cell apoptotic processsearch positive regulation of MHC class II biosynthetic processsearch negative regulation of interleukin-17 productionsearch positive regulation of killing of cells of other organismsearch negative regulation of growth of symbiont involved in interaction with hostsearch CD8-positive, alpha-beta T cell differentiation involved in immune responsesearch positive regulation of membrane protein ectodomain proteolysissearch positive regulation of nitric oxide biosynthetic processsearch negative regulation of smooth muscle cell proliferationsearch cell cycle arrestsearch positive regulation of cell proliferationsearch positive regulation of tyrosine phosphorylation of Stat1 proteinsearch humoral immune responsesearch protein import into nucleus, translocationsearch positive regulation of isotype switching to IgG isotypessearch positive regulation of calcidiol 1-monooxygenase activitysearch positive regulation of interleukin-12 biosynthetic processsearch positive regulation of transcription from RNA polymerase II promotersearch positive regulation of tumor necrosis factor productionsearch positive regulation of synaptic transmission, cholinergicsearch negative regulation of epithelial cell differentiationsearch regulation of insulin secretionsearch positive regulation of mesenchymal cell proliferationsearch cytokine-mediated signaling pathwaysearch regulation of the force of heart contractionsearch cellular component movementsearch cellular response to interleukin-18search endoplasmic reticulum unfolded protein responsesearch response to virussearch positive regulation of osteoclast differentiationsearch cellular response to lipopolysaccharidesearch positive regulation of interleukin-6 biosynthetic processsearch neutrophil chemotaxissearch negative regulation of growth of symbiont in hostsearch positive regulation of smooth muscle cell apoptotic processsearch positive regulation of vitamin D biosynthetic processsearch positive regulation of fructose 1,6-bisphosphate 1-phosphatase activitysearch positive regulation of interleukin-1 beta secretionsearch response to drugsearch regulation of transcription, DNA-templatedsearch regulation of growthsearch interferon-gamma-mediated signaling pathwaysearch positive regulation of interleukin-23 productionsearch regulation of interferon-gamma-mediated signaling pathwaysearch cytokine activitysearch interferon-gamma receptor bindingsearch
C, D, E (P15260) membranesearch cytokine bindingsearch

Chain InterPro annotation
A, B Interferon gammasearch Four-helical cytokine-like, coresearch Four-helical cytokine, coresearch
C, D, E Fibronectin type IIIsearch Interferon gamma receptor alpha subunitsearch Immunoglobulin-like foldsearch Interferon gamma receptor, poxvirus/mammalsearch