1fg9 Summary

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3:1 COMPLEX OF INTERFERON-GAMMA RECEPTOR WITH INTERFERON-GAMMA DIMER

The structure was published by Thiel, D.J., le Du, M.H., Walter, R.L., et al., Garotta, G., Winkler, F.K., and Ealick, S.E., in 2000 in a paper entitled "Observation of an unexpected third receptor molecule in the crystal structure of human interferon-gamma receptor complex." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2000.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely INTERFERON GAMMA and INTERFERON-GAMMA RECEPTOR ALPHA CHAIN.

The molecule most likely forms heteropentamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A INTERFERON GAMMA P01579 (24-156) (IFNG_HUMAN)search Homo sapienssearch 90% 134 94%
B INTERFERON GAMMA P01579 (24-156) (IFNG_HUMAN)search Homo sapienssearch 90% 134 94%
C INTERFERON-GAMMA RECEPTOR ALPHA CHAIN P15260 (18-262) (INGR1_HUMAN)search Homo sapienssearch < 90% 245 85%
D INTERFERON-GAMMA RECEPTOR ALPHA CHAIN P15260 (18-262) (INGR1_HUMAN)search Homo sapienssearch < 90% 245 85%
E INTERFERON-GAMMA RECEPTOR ALPHA CHAIN P15260 (18-262) (INGR1_HUMAN)search Homo sapienssearch < 90% 245 85%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P01579 (24 - 156) INTERFERON GAMMA Homo sapiens
P15260 (18 - 262) INTERFERON-GAMMA RECEPTOR ALPHA CHAIN Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P01579) Interferons/interleukin-10 (IL-10)search Growth Hormone; Chain: A;search PF00714: Interferon gammasearch
C, D, E Fibronectin type IIIsearch Immunoglobulinssearch Tissue factorsearch, Interferon gamma receptor (IFNGR1)search

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, B (P01579) extracellular regionsearch extracellular spacesearch external side of plasma membranesearch negative regulation of growth of symbiont in hostsearch defense response to virussearch positive regulation of MHC class II biosynthetic processsearch positive regulation of cell proliferationsearch positive regulation of tyrosine phosphorylation of Stat1 proteinsearch regulation of transcription, DNA-templatedsearch protein import into nucleus, translocationsearch regulation of neuronal action potentialsearch regulation of growthsearch positive regulation of neuron differentiationsearch negative regulation of transcription from RNA polymerase II promotersearch positive regulation of mesenchymal cell proliferationsearch cellular response to lipopolysaccharidesearch inflammatory cell apoptotic processsearch sensory perception of mechanical stimulussearch positive regulation of membrane protein ectodomain proteolysissearch cell cycle arrestsearch positive regulation of interleukin-1 beta secretionsearch negative regulation of metanephric nephron tubule epithelial cell differentiationsearch positive regulation of nitric oxide biosynthetic processsearch negative regulation of smooth muscle cell proliferationsearch immune responsesearch positive regulation of synaptic transmission, cholinergicsearch response to virussearch endoplasmic reticulum unfolded protein responsesearch positive regulation of osteoclast differentiationsearch antigen processing and presentationsearch cellular component movementsearch negative regulation of myelinationsearch negative regulation of epithelial cell differentiationsearch regulation of insulin secretionsearch cytokine-mediated signaling pathwaysearch positive regulation of peptidyl-serine phosphorylation of STAT proteinsearch positive regulation of calcidiol 1-monooxygenase activitysearch apoptotic processsearch regulation of hepatocyte proliferationsearch humoral immune responsesearch defense response to bacteriumsearch neutrophil apoptotic processsearch positive regulation of interleukin-12 biosynthetic processsearch positive regulation of cell adhesionsearch regulation of interferon-gamma-mediated signaling pathwaysearch neutrophil chemotaxissearch adaptive immune responsesearch interferon-gamma-mediated signaling pathwaysearch negative regulation of growth of symbiont involved in interaction with hostsearch positive regulation of isotype switching to IgG isotypessearch positive regulation of tumor necrosis factor productionsearch positive regulation of interleukin-12 productionsearch positive regulation of fructose 1,6-bisphosphate 1-phosphatase activitysearch cellular response to interleukin-18search defense response to protozoansearch positive regulation of interleukin-6 biosynthetic processsearch positive regulation of transcription from RNA polymerase II promotersearch positive regulation of transcription, DNA-templatedsearch negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesissearch regulation of the force of heart contractionsearch positive regulation of smooth muscle cell apoptotic processsearch positive regulation of vitamin D biosynthetic processsearch positive regulation of fructose 1,6-bisphosphate metabolic processsearch positive regulation of chemokine biosynthetic processsearch positive regulation of interleukin-23 productionsearch response to drugsearch negative regulation of cell proliferationsearch regulation of immune responsesearch positive regulation of tumor necrosis factor (ligand) superfamily member 11 productionsearch cell surface receptor signaling pathwaysearch CD8-positive, alpha-beta T cell differentiation involved in immune responsesearch extrinsic apoptotic signaling pathwaysearch positive regulation of T cell proliferationsearch negative regulation of interleukin-17 productionsearch positive regulation of killing of cells of other organismsearch cytokine activitysearch interferon-gamma receptor bindingsearch
C, D, E (P15260) membranesearch cytokine bindingsearch

Chain InterPro annotation
A, B Interferon gammasearch Four-helical cytokine-like, coresearch Four-helical cytokine, coresearch
C, D, E Fibronectin type IIIsearch Interferon gamma receptor alpha subunitsearch Immunoglobulin-like foldsearch Interferon gamma receptor, poxvirus/mammalsearch