1fg9 Summary

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3:1 COMPLEX OF INTERFERON-GAMMA RECEPTOR WITH INTERFERON-GAMMA DIMER

The structure was published by Thiel, D.J., le Du, M.H., Walter, R.L., et al., Garotta, G., Winkler, F.K., and Ealick, S.E., in 2000 in a paper entitled "Observation of an unexpected third receptor molecule in the crystal structure of human interferon-gamma receptor complex." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2000.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely INTERFERON GAMMA and INTERFERON-GAMMA RECEPTOR ALPHA CHAIN.

The molecule most likely forms heteropentamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A INTERFERON GAMMA P01579 (24-156) (IFNG_HUMAN)search Homo sapienssearch 90% 134 94%
B INTERFERON GAMMA P01579 (24-156) (IFNG_HUMAN)search Homo sapienssearch 90% 134 94%
C INTERFERON-GAMMA RECEPTOR ALPHA CHAIN P15260 (18-262) (INGR1_HUMAN)search Homo sapienssearch < 90% 245 85%
D INTERFERON-GAMMA RECEPTOR ALPHA CHAIN P15260 (18-262) (INGR1_HUMAN)search Homo sapienssearch < 90% 245 85%
E INTERFERON-GAMMA RECEPTOR ALPHA CHAIN P15260 (18-262) (INGR1_HUMAN)search Homo sapienssearch < 90% 245 85%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P01579 (24 - 156) INTERFERON GAMMA Homo sapiens
P15260 (18 - 262) INTERFERON-GAMMA RECEPTOR ALPHA CHAIN Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P01579) Interferons/interleukin-10 (IL-10)search Growth Hormone; Chain: A;search PF00714: Interferon gammasearch
C, D, E Fibronectin type IIIsearch Immunoglobulinssearch Tissue factorsearch, Interferon gamma receptor (IFNGR1)search

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, B (P01579) positive regulation of peptidyl-serine phosphorylation of STAT proteinsearch positive regulation of interleukin-12 productionsearch negative regulation of interleukin-17 productionsearch positive regulation of killing of cells of other organismsearch apoptotic processsearch positive regulation of tumor necrosis factor productionsearch positive regulation of membrane protein ectodomain proteolysissearch adaptive immune responsesearch positive regulation of tyrosine phosphorylation of Stat1 proteinsearch defense response to protozoansearch positive regulation of transcription from RNA polymerase II promotersearch positive regulation of cell proliferationsearch regulation of hepatocyte proliferationsearch protein import into nucleus, translocationsearch cell cycle arrestsearch positive regulation of interleukin-1 beta secretionsearch positive regulation of interleukin-12 biosynthetic processsearch positive regulation of MHC class II biosynthetic processsearch positive regulation of nitric oxide biosynthetic processsearch negative regulation of smooth muscle cell proliferationsearch negative regulation of metanephric nephron tubule epithelial cell differentiationsearch humoral immune responsesearch positive regulation of interleukin-6 biosynthetic processsearch regulation of insulin secretionsearch neutrophil apoptotic processsearch positive regulation of calcidiol 1-monooxygenase activitysearch negative regulation of transcription from RNA polymerase II promotersearch negative regulation of growth of symbiont involved in interaction with hostsearch positive regulation of mesenchymal cell proliferationsearch regulation of immune responsesearch CD8-positive, alpha-beta T cell differentiation involved in immune responsesearch neutrophil chemotaxissearch negative regulation of epithelial cell differentiationsearch cellular component movementsearch response to virussearch positive regulation of osteoclast differentiationsearch positive regulation of chemokine biosynthetic processsearch negative regulation of cell proliferationsearch cytokine-mediated signaling pathwaysearch positive regulation of T cell proliferationsearch defense response to virussearch negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesissearch regulation of growthsearch response to drugsearch defense response to bacteriumsearch positive regulation of smooth muscle cell apoptotic processsearch positive regulation of vitamin D biosynthetic processsearch positive regulation of fructose 1,6-bisphosphate 1-phosphatase activitysearch regulation of interferon-gamma-mediated signaling pathwaysearch inflammatory cell apoptotic processsearch negative regulation of myelinationsearch negative regulation of growth of symbiont in hostsearch interferon-gamma-mediated signaling pathwaysearch positive regulation of synaptic transmission, cholinergicsearch regulation of neuronal action potentialsearch endoplasmic reticulum unfolded protein responsesearch cellular response to lipopolysaccharidesearch antigen processing and presentationsearch cell surface receptor signaling pathwaysearch positive regulation of cell adhesionsearch positive regulation of tumor necrosis factor (ligand) superfamily member 11 productionsearch positive regulation of transcription, DNA-templatedsearch positive regulation of interleukin-23 productionsearch regulation of the force of heart contractionsearch positive regulation of fructose 1,6-bisphosphate metabolic processsearch sensory perception of mechanical stimulussearch regulation of transcription, DNA-templatedsearch extrinsic apoptotic signaling pathwaysearch cellular response to interleukin-18search positive regulation of neuron differentiationsearch positive regulation of isotype switching to IgG isotypessearch immune responsesearch extracellular regionsearch external side of plasma membranesearch extracellular spacesearch cytokine activitysearch interferon-gamma receptor bindingsearch
C, D, E (P15260) membranesearch cytokine bindingsearch

Chain InterPro annotation
A, B Interferon gammasearch Four-helical cytokine-like, coresearch Four-helical cytokine, coresearch
C, D, E Fibronectin type IIIsearch Interferon gamma receptor alpha subunitsearch Immunoglobulin-like foldsearch Interferon gamma receptor, poxvirus/mammalsearch