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3:1 COMPLEX OF INTERFERON-GAMMA RECEPTOR WITH INTERFERON-GAMMA DIMER

X-ray diffraction
2.9Å resolution
PDB entry 1fg9 coloured by chain, front view.
PDB entry 1fg9 coloured by chain, side view.
PDB entry 1fg9 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero pentamer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Interferon gamma complex and Interferon gamma receptor 1
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Multimeric state: hetero pentamer
Accessible surface area: 44362.48 Å2
Buried surface area: 12937.63 Å2
Dissociation area: 2,621.63 Å2
Dissociation energy (ΔGdiss): -10.35 kcal/mol
Dissociation entropy (TΔSdiss): 39.26 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134403

Macromolecules

Interferon gamma
Chains: A, B
Length: 134 amino acids
Theoretical weight: 15.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01579 (Residues: 24-156; Coverage: 93%)
Gene name: IFNG
Pfam: Interferon gamma
InterPro:
CATH: Growth Hormone; Chain: A;
SCOP: Interferons/interleukin-10 (IL-10)
Interferon gamma in PDB entry 1fg9, assembly 1, front view.
Interferon gamma in PDB entry 1fg9, assembly 1, side view.
Interferon gamma in PDB entry 1fg9, assembly 1, top view.
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Interferon gamma receptor 1
Chains: C, D, E
Length: 245 amino acids
Theoretical weight: 27.65 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: P15260 (Residues: 18-262; Coverage: 52%)
Gene name: IFNGR1
Pfam:
InterPro:
CATH: Immunoglobulins
SCOP: Fibronectin type III
Interferon gamma receptor 1 in PDB entry 1fg9, assembly 1, front view.
Interferon gamma receptor 1 in PDB entry 1fg9, assembly 1, side view.
Interferon gamma receptor 1 in PDB entry 1fg9, assembly 1, top view.
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