1ff1 Summary

pdbe.org/1ff1
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STRUCTURE OF THE SECOND EPS15 HOMOLOGY DOMAIN OF HUMAN EPS15 IN COMPLEX WITH PTGSSSTNPFL

The structure was published by de Beer, T., Hoofnagle, A.N., Enmon, J.L., et al., Yamabhai, M., Kay, B.K., and Overduin, M., in 2000 in a paper entitled "Molecular mechanism of NPF recognition by EH domains." (abstract).

The structure was determined using NMR spectroscopy and deposited in 2000.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely EPIDERMAL GROWTH FACTOR RECEPTOR SUBSTRATE 15 and PTGSSSTNPFL PEPTIDE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A EPIDERMAL GROWTH FACTOR RECEPTOR SUBSTRATE 15 P42566 (121-215) (EPS15_HUMAN)search Homo sapienssearch < 90% 95 100%
B PTGSSSTNPFL PEPTIDE Not available
Synthetic Not available 11 54%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P42566 (121 - 215) EPIDERMAL GROWTH FACTOR RECEPTOR SUBSTRATE 15 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH)
A Eps15 homology domain (EH domain)search EF-handsearch
B

Chain ID Molecular function (GO)
A (P42566) calcium ion bindingsearch

Chain InterPro annotation
A EPS15 homology (EH)search EF-hand domainsearch EF-hand domain pairsearch EF-Hand 1, calcium-binding sitesearch
B