1fdy Summary

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N-ACETYLNEURAMINATE LYASE IN COMPLEX WITH HYDROXYPYRUVATE

The structure was published by Lawrence, M.C., Barbosa, J.A., Smith, B.J., et al., Pilling, P.A., Ooi, H.C., and Marcuccio, S.M., in 1997 in a paper entitled "Structure and mechanism of a sub-family of enzymes related to N-acetylneuraminate lyase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.45 Å and deposited in 1996.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of N-ACETYLNEURAMINATE LYASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A N-ACETYLNEURAMINATE LYASE P0A6L4 (1-297) (NANA_ECOLI)search Escherichia coli K-12search 99% 297 98%
B N-ACETYLNEURAMINATE LYASE P0A6L4 (1-297) (NANA_ECOLI)search Escherichia coli K-12search 99% 297 98%
C N-ACETYLNEURAMINATE LYASE P0A6L4 (1-297) (NANA_ECOLI)search Escherichia coli K-12search 99% 297 98%
D N-ACETYLNEURAMINATE LYASE P0A6L4 (1-297) (NANA_ECOLI)search Escherichia coli K-12search 99% 297 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P0A6L4 (1 - 297) N-ACETYLNEURAMINATE LYASE Escherichia coli

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D (P0A6L4) Class I aldolasesearch Aldolase class Isearch PF00701: Dihydrodipicolinate synthetase familysearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B, C, D (P0A6L4) identical protein bindingsearch catalytic activitysearch N-acetylneuraminate lyase activitysearch lyase activitysearch carbohydrate metabolic processsearch N-acetylneuraminate catabolic processsearch metabolic processsearch cytoplasmsearch

Chain InterPro annotation
A, B, C, D DapA-likesearch N-acetylneuraminate lyasesearch Aldolase-type TIM barrelsearch Dihydrodipicolinate synthetase, conserved sitesearch Dihydrodipicolinate synthetase, active sitesearch