1fdh Summary

pdbe.org/1fdh
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STRUCTURE OF HUMAN FOETAL DEOXYHAEMOGLOBIN

The structure was published by Frier, J.A. and Perutz, M.F., in 1977 in a paper entitled "Structure of human foetal deoxyhaemoglobin." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 1976.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN F (DEOXY) (ALPHA CHAIN) and HEMOGLOBIN F (DEOXY) (GAMMA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN F (DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN F (DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
G HEMOGLOBIN F (DEOXY) (GAMMA CHAIN) P69892 (2-147) (HBG2_HUMAN)search Homo sapienssearch 99% 147 100%
H HEMOGLOBIN F (DEOXY) (GAMMA CHAIN) P69892 (2-147) (HBG2_HUMAN)search Homo sapienssearch 99% 147 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN F (DEOXY) (ALPHA CHAIN) Homo sapiens
P69892 (2 - 147) HEMOGLOBIN F (DEOXY) (GAMMA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P69905) Globinssearch Globinssearch PF00042: Globinsearch
G, H (P69892) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P69905) oxygen transportsearch bicarbonate transportsearch response to hydrogen peroxidesearch hydrogen peroxide catabolic processsearch positive regulation of cell deathsearch protein heterooligomerizationsearch receptor-mediated endocytosissearch small molecule metabolic processsearch oxidation-reduction processsearch transportsearch heme bindingsearch protein bindingsearch oxygen bindingsearch haptoglobin bindingsearch peroxidase activitysearch iron ion bindingsearch metal ion bindingsearch oxygen transporter activitysearch blood microparticlesearch cytosolic small ribosomal subunitsearch cytosolsearch extracellular regionsearch hemoglobin complexsearch extracellular exosomesearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch membranesearch
G, H (P69892) transportsearch oxygen transportsearch blood coagulationsearch iron ion bindingsearch heme bindingsearch oxygen bindingsearch metal ion bindingsearch oxygen transporter activitysearch hemoglobin complexsearch cytosolsearch blood microparticlesearch

Chain InterPro annotation
A, B Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
G, H Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch