1fdh Summary

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STRUCTURE OF HUMAN FOETAL DEOXYHAEMOGLOBIN

The structure was published by Frier, J.A. and Perutz, M.F., in 1977 in a paper entitled "Structure of human foetal deoxyhaemoglobin." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 1976.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN F (DEOXY) (ALPHA CHAIN) and HEMOGLOBIN F (DEOXY) (GAMMA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN F (DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN F (DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
G HEMOGLOBIN F (DEOXY) (GAMMA CHAIN) P69892 (2-147) (HBG2_HUMAN)search Homo sapienssearch 99% 147 100%
H HEMOGLOBIN F (DEOXY) (GAMMA CHAIN) P69892 (2-147) (HBG2_HUMAN)search Homo sapienssearch 99% 147 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN F (DEOXY) (ALPHA CHAIN) Homo sapiens
P69892 (2 - 147) HEMOGLOBIN F (DEOXY) (GAMMA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P69905) Globinssearch Globinssearch PF00042: Globinsearch
G, H (P69892) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P69905) iron ion bindingsearch oxygen transporter activitysearch protein bindingsearch heme bindingsearch haptoglobin bindingsearch metal ion bindingsearch peroxidase activitysearch oxygen bindingsearch oxygen transportsearch bicarbonate transportsearch oxidation-reduction processsearch response to hydrogen peroxidesearch hydrogen peroxide catabolic processsearch positive regulation of cell deathsearch small molecule metabolic processsearch protein heterooligomerizationsearch transportsearch blood microparticlesearch cytosolsearch cytosolic small ribosomal subunitsearch extracellular regionsearch extracellular vesicular exosomesearch hemoglobin complexsearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch membranesearch
G, H (P69892) oxygen bindingsearch metal ion bindingsearch oxygen transporter activitysearch heme bindingsearch iron ion bindingsearch oxygen transportsearch transportsearch blood coagulationsearch cytosolsearch blood microparticlesearch hemoglobin complexsearch

Chain InterPro annotation
A, B Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
G, H Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch