1fdh Summary

pdbe.org/1fdh
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STRUCTURE OF HUMAN FOETAL DEOXYHAEMOGLOBIN

The structure was published by Frier, J.A. and Perutz, M.F., in 1977 in a paper entitled "Structure of human foetal deoxyhaemoglobin." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 1976.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN F (DEOXY) (ALPHA CHAIN) and HEMOGLOBIN F (DEOXY) (GAMMA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN F (DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN F (DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
G HEMOGLOBIN F (DEOXY) (GAMMA CHAIN) P69892 (2-147) (HBG2_HUMAN)search Homo sapienssearch 99% 147 100%
H HEMOGLOBIN F (DEOXY) (GAMMA CHAIN) P69892 (2-147) (HBG2_HUMAN)search Homo sapienssearch 99% 147 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN F (DEOXY) (ALPHA CHAIN) Homo sapiens
P69892 (2 - 147) HEMOGLOBIN F (DEOXY) (GAMMA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P69905) Globinssearch Globinssearch PF00042: Globinsearch
G, H (P69892) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B (P69905) peroxidase activitysearch haptoglobin bindingsearch oxygen transporter activitysearch iron ion bindingsearch protein bindingsearch oxygen bindingsearch heme bindingsearch metal ion bindingsearch extracellular regionsearch cytosolsearch hemoglobin complexsearch membranesearch cytosolic small ribosomal subunitsearch haptoglobin-hemoglobin complexsearch extracellular vesicular exosomesearch endocytic vesicle lumensearch blood microparticlesearch transportsearch receptor-mediated endocytosissearch positive regulation of cell deathsearch oxygen transportsearch bicarbonate transportsearch response to hydrogen peroxidesearch hydrogen peroxide catabolic processsearch small molecule metabolic processsearch protein heterooligomerizationsearch oxidation-reduction processsearch
G, H (P69892) oxygen transporter activitysearch iron ion bindingsearch oxygen bindingsearch heme bindingsearch metal ion bindingsearch cytosolsearch hemoglobin complexsearch blood microparticlesearch transportsearch blood coagulationsearch oxygen transportsearch

Chain InterPro annotation
A, B Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
G, H Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch