1fd0 Summary

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ISOTYPE SELECTIVITY OF THE HUMAN RETINOIC ACID NUCLEAR RECEPTOR HRAR: THE COMPLEX WITH THE RARGAMMA-SELECTIVE RETINOID SR11254

The structure was published by Klaholz, B. and Moras, D., in 2002 in a paper entitled "C-H...O hydrogen bonds in the nuclear receptor RARgamma--a potential tool for drug selectivity." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.38 Å and deposited in 2000.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of RETINOIC ACID RECEPTOR GAMMA-1. This molecule has the UniProt identifier P13631 (RARG_HUMAN)search. The sample contained 235 residues which is < 90% of the natural sequence. Out of 235 residues 235 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A RETINOIC ACID RECEPTOR GAMMA-1 P13631 (183-417) (RARG_HUMAN)search Homo sapienssearch < 90% 235 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P13631 (183 - 417) RETINOIC ACID RECEPTOR GAMMA-1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P13631) DNA bindingsearch steroid hormone receptor activitysearch sequence-specific DNA binding transcription factor activitysearch retinoic acid receptor activitysearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch retinoic acid receptor signaling pathwaysearch nucleussearch

Chain InterPro annotation
A Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Retinoic acid receptorsearch Nuclear hormone receptor, ligand-bindingsearch