1fbz Summary

pdbe.org/1fbz
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Structure-based design of a novel, osteoclast-selective, nonpeptide Src SH2 inhibitor with in vivo anti-resorptive activity

The structure was published by Shakespeare, W., Yang, M., Bohacek, R., et al., Iuliucci, J., Weigele, M., and Sawyer, T., in 2000 in a paper entitled "Structure-based design of an osteoclast-selective, nonpeptide src homology 2 inhibitor with in vivo antiresorptive activity." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2000.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of PROTO-ONCOGENE TYROSINE-PROTEIN KINASE LCK.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTO-ONCOGENE TYROSINE-PROTEIN KINASE LCK P06239 (123-226) (LCK_HUMAN)search Homo sapienssearch < 90% 104 100%
B PROTO-ONCOGENE TYROSINE-PROTEIN KINASE LCK P06239 (123-226) (LCK_HUMAN)search Homo sapienssearch < 90% 104 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P06239 (123 - 226) PROTO-ONCOGENE TYROSINE-PROTEIN KINASE LCK Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B SH2 domainsearch SHC Adaptor Proteinsearch SH2 domainsearch
Chain InterPro annotation
A, B SH2 domainsearch