Structure-based design of a novel, osteoclast-selective, nonpeptide Src SH2 inhibitor with in vivo anti-resorptive activity
The structure was published by Shakespeare, W., Yang, M., Bohacek, R., et al., Iuliucci, J., Weigele, M., and Sawyer, T., in 2000 in a paper entitled "Structure-based design of an osteoclast-selective, nonpeptide src homology 2 inhibitor with in vivo antiresorptive activity." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2000.
The experimental data on which the structure is based was not deposited.
This PDB entry contains multiple copies of the structure of PROTO-ONCOGENE TYROSINE-PROTEIN KINASE LCK.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: