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CRYSTAL STRUCTURE OF ZINC-CONTAINING E.COLI GTP CYCLOHYDROLASE I

The structure was published by Auerbach, G., Herrmann, A., Bracher, A., et al., Nar, H., Huber, R., and Bacher, A., in 2000 in a paper entitled "Zinc plays a key role in human and bacterial GTP cyclohydrolase I." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2000.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of GTP CYCLOHYDROLASE I.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A GTP CYCLOHYDROLASE I P0A6T5 (2-222) (GCH1_ECOLI)search Escherichia coli K-12search 100% 221 100%
B GTP CYCLOHYDROLASE I P0A6T5 (2-222) (GCH1_ECOLI)search Escherichia coli K-12search 100% 221 100%
C GTP CYCLOHYDROLASE I P0A6T5 (2-222) (GCH1_ECOLI)search Escherichia coli K-12search 100% 221 100%
D GTP CYCLOHYDROLASE I P0A6T5 (2-222) (GCH1_ECOLI)search Escherichia coli K-12search 100% 221 100%
E GTP CYCLOHYDROLASE I P0A6T5 (2-222) (GCH1_ECOLI)search Escherichia coli K-12search 100% 221 100%
F GTP CYCLOHYDROLASE I P0A6T5 (2-222) (GCH1_ECOLI)search Escherichia coli K-12search 100% 221 100%
G GTP CYCLOHYDROLASE I P0A6T5 (2-222) (GCH1_ECOLI)search Escherichia coli K-12search 100% 221 100%
H GTP CYCLOHYDROLASE I P0A6T5 (2-222) (GCH1_ECOLI)search Escherichia coli K-12search 100% 221 100%
I GTP CYCLOHYDROLASE I P0A6T5 (2-222) (GCH1_ECOLI)search Escherichia coli K-12search 100% 221 100%
J GTP CYCLOHYDROLASE I P0A6T5 (2-222) (GCH1_ECOLI)search Escherichia coli K-12search 100% 221 100%
K GTP CYCLOHYDROLASE I P0A6T5 (2-222) (GCH1_ECOLI)search Escherichia coli K-12search 100% 221 100%
L GTP CYCLOHYDROLASE I P0A6T5 (2-222) (GCH1_ECOLI)search Escherichia coli K-12search 100% 221 100%
M GTP CYCLOHYDROLASE I P0A6T5 (2-222) (GCH1_ECOLI)search Escherichia coli K-12search 100% 221 100%
N GTP CYCLOHYDROLASE I P0A6T5 (2-222) (GCH1_ECOLI)search Escherichia coli K-12search 100% 221 100%
O GTP CYCLOHYDROLASE I P0A6T5 (2-222) (GCH1_ECOLI)search Escherichia coli K-12search 100% 221 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P0A6T5 (2 - 222) GTP CYCLOHYDROLASE I Escherichia coli

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D, E, F, G, H, I, J, K, L, M, N, O (P0A6T5) GTP cyclohydrolase Isearch GTP Cyclohydrolase I; Chain A, domain 1search, GTP Cyclohydrolase I, domain 2search PF01227: GTP cyclohydrolase Isearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B, C, D, E, F, G, H, I, J, K, L, M, N, O (P0A6T5) metabolic processsearch tetrahydrofolate biosynthetic processsearch queuosine biosynthetic processsearch one-carbon metabolic processsearch 7,8-dihydroneopterin 3'-triphosphate biosynthetic processsearch GTP bindingsearch zinc ion bindingsearch nucleotide bindingsearch GTP cyclohydrolase I activitysearch catalytic activitysearch hydrolase activitysearch metal ion bindingsearch protein complexsearch cytoplasmsearch

Chain InterPro annotation
A, B, C, D, E, F, G, H, I, J, K, L, M, N, O GTP cyclohydrolase Isearch GTP cyclohydrolase I, conserved sitesearch GTP cyclohydrolase I domainsearch