1fbv Summary

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STRUCTURE OF A CBL-UBCH7 COMPLEX: RING DOMAIN FUNCTION IN UBIQUITIN-PROTEIN LIGASES

There is a Quite Interesting Protein Structure article for this entry.

The structure was published by Zheng, N., Wang, P., Jeffrey, P.D., and Pavletich, N.P., in 2000 in a paper entitled "Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2000.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely SIGNAL TRANSDUCTION PROTEIN CBL, ZAP-70 PEPTIDE, and UBIQUITIN-CONJUGATING ENZYME E12-18 KDA UBCH7.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A SIGNAL TRANSDUCTION PROTEIN CBL P22681 (47-434) (CBL_HUMAN)search Homo sapienssearch < 90% 388 100%
B ZAP-70 PEPTIDE P43403 (289-297) (ZAP70_HUMAN)search Homo sapienssearch 98% 9 100%
C UBIQUITIN-CONJUGATING ENZYME E12-18 KDA UBCH7 P68036 (1-154) (UB2L3_HUMAN)search Homo sapienssearch 100% 154 93%


This entry contains 3 unique UniProt proteins:

UniProt accession Name Organism PDB
P22681 (47 - 434) SIGNAL TRANSDUCTION PROTEIN CBL Homo sapiens
P43403 (289 - 297) ZAP-70 PEPTIDE
P68036 (1 - 154) UBIQUITIN-CONJUGATING ENZYME E12-18 KDA UBCH7 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A EF-hand modules in multidomain proteinssearch, N-terminal domain of cbl (N-cbl)search, SH2 domainsearch, RING finger domain, C3HC4search EF-handsearch, Zinc/RING finger domain, C3HC4 (zinc finger)search, SHC Adaptor Proteinsearch, N-terminal domain of cbl (N-cbl)search Zinc finger, C3HC4 type (RING finger)search, CBL proto-oncogene N-terminal domain 1search, CBL proto-oncogene N-terminus, EF hand-like domainsearch, CBL proto-oncogene N-terminus, SH2-like domainsearch
B (P43403)
C (P68036) UBC-relatedsearch Ubiquitin Conjugating Enzymesearch PF00179: Ubiquitin-conjugating enzymesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P22681) cell surface receptor signaling pathwaysearch regulation of signalingsearch calcium ion bindingsearch ubiquitin-protein transferase activitysearch zinc ion bindingsearch phosphotyrosine bindingsearch signal transducer activitysearch nucleussearch
C (P68036) regulation of transcription, DNA-templatedsearch cell cycle phase transitionsearch protein ubiquitinationsearch protein polyubiquitinationsearch ubiquitin-dependent protein catabolic processsearch protein K11-linked ubiquitinationsearch positive regulation of ubiquitin-protein transferase activitysearch cellular protein modification processsearch transcription, DNA-templatedsearch cell proliferationsearch cellular response to steroid hormone stimulussearch cellular response to glucocorticoid stimulussearch positive regulation of protein ubiquitinationsearch acid-amino acid ligase activitysearch protein bindingsearch ubiquitin protein ligase bindingsearch ubiquitin-protein transferase activitysearch ATP bindingsearch enzyme bindingsearch ubiquitin conjugating enzyme activitysearch ligase activitysearch nucleotide bindingsearch ubiquitin-protein transferase activator activitysearch poly(A) RNA bindingsearch transcription coactivator activitysearch nucleussearch ubiquitin ligase complexsearch cytoplasmsearch extracellular vesicular exosomesearch

Chain InterPro annotation
A SH2 domainsearch Zinc finger, RING-typesearch Adaptor protein Cbl, N-terminal helicalsearch EF-hand domain pairsearch Zinc finger, RING/FYVE/PHD-typesearch Adaptor protein Cbl, EF hand-likesearch Adaptor protein Cbl, SH2-likesearch Zinc finger, RING-type, conserved sitesearch Adaptor protein Cbl, PTB domainsearch Adaptor protein Cblsearch
B
C Ubiquitin-conjugating enzyme E2search Ubiquitin-conjugating enzyme/RWD-likesearch Ubiquitin-conjugating enzyme, active sitesearch