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THE STRUCTURE OF AN HIV-1 SPECIFIC CELL ENTRY INHIBITOR IN COMPLEX WITH THE HIV-1 GP41 TRIMERIC CORE

The structure was published by Zhou, G., Ferrer, M., Chopra, R., et al., Schreiber, S.L., Harrison, S.C., and Wiley, D.C., in 2000 in a paper entitled "The structure of an HIV-1 specific cell entry inhibitor in complex with the HIV-1 gp41 trimeric core." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.0 Å and deposited in 2000.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HIV-1 ENVELOPE PROTEIN CHIMERA and PROTEIN (TRANSMEMBRANE GLYCOPROTEIN).

The molecule most likely forms heterohexamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HIV-1 ENVELOPE PROTEIN CHIMERA P03069 (252-280) (GCN4_YEAST)search ,
P03377 (546-595) (ENV_HV1BR)search
Saccharomyces cerevisiae S288csearch ,
Human immunodeficiency virus type 1 (BRU ISOLATE)search
< 90% ,
< 90%
79 98%
C PROTEIN (TRANSMEMBRANE GLYCOPROTEIN) P03377 (639-670) (ENV_HV1BR)search Human immunodeficiency virus type 1 (BRU ISOLATE)search < 90% 33 93%


Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Virus ectodomainsearch Helix Hairpinssearch bZIP transcription factorsearch, Retroviral envelope proteinsearch
C Virus ectodomainsearch Retroviral envelope proteinsearch

Chain ID Molecular function (GO) Cellular component (GO)
A (P03069P03377) structural molecule activitysearch viral envelopesearch

Chain InterPro annotation
A Retroviral envelope proteinsearch
C