PDB entry 1fao

STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN FROM DAPP1/PHISH IN COMPLEX WITH INOSITOL 1,3,4,5-TETRAKISPHOSPHATE

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The structure was published by Ferguson, K.M., Kavran, J.M., Sankaran, V.G., et al., Isakoff, S.J., Skolnik, E.Y., and Lemmon, M.A., in 2000 in a paper entitled "Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2000.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of DUAL ADAPTOR OF PHOSPHOTYROSINE AND 3-PHOSPHOINOSITIDES. This molecule has the UniProt identifier Q9UN19 (DAPP1_HUMAN). The sample contained 126 residues which is < 90% of the natural sequence. Out of 126 residues 100 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain	Name	UniProt	Name of source organism	% of UniProt sequence present in the sample	Residues in the sample molecules	% of residues observed
A	DUAL ADAPTOR OF PHOSPHOTYROSINE AND 3-PHOSPHOINOSITIDES	Q9UN19 (148-273) (DAPP1_HUMAN)	Homo sapiens	< 90%	126	79%

This entry contains 1 unique UniProt protein:

UniProt accession	Name	Organism	PDB
Q9UN19 (148 - 273)	DUAL ADAPTOR OF PHOSPHOTYROSINE AND 3-PHOSPHOINOSITIDES	Homo sapiens	Related PDB sequences UniProt coverage

Chain	Structural classification (SCOP)	Structural classification (CATH)	Sequence family (Pfam)
A	Pleckstrin-homology domain (PH domain)	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	PH domain, SH2 domain

Chain ID	Molecular function (GO)
A	Protein binding

Chain	InterPro annotation
A	SH2 domain, Pleckstrin homology domain, Pleckstrin homology-like domain