1f8m Summary

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CRYSTAL STRUCTURE OF 3-BROMOPYRUVATE MODIFIED ISOCITRATE LYASE (ICL) FROM MYCOBACTERIUM TUBERCULOSIS

The structure was published by Sharma, V., Sharma, S., Hoener zu Bentrup, K., et al., Russell, D.G., Jacobs Jr., W.R., and Sacchettini, J.C., in 2000 in a paper entitled "Structure of isocitrate lyase, a persistence factor of Mycobacterium tuberculosis." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2000.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of ISOCITRATE LYASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A ISOCITRATE LYASE P9WKK6 (2-428) (ACEA_MYCTO)search Mycobacterium tuberculosis CDC1551search 100% 429 99%
B ISOCITRATE LYASE P9WKK6 (2-428) (ACEA_MYCTO)search Mycobacterium tuberculosis CDC1551search 100% 429 99%
C ISOCITRATE LYASE P9WKK6 (2-428) (ACEA_MYCTO)search Mycobacterium tuberculosis CDC1551search 100% 429 99%
D ISOCITRATE LYASE P9WKK6 (2-428) (ACEA_MYCTO)search Mycobacterium tuberculosis CDC1551search 100% 429 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P9WKK6 (2 - 428) ISOCITRATE LYASE Mycobacterium tuberculosis H37Rv

Chain Structural classification (SCOP) Structural classification (CATH)
A, B, C, D Phosphoenolpyruvate mutase/Isocitrate lyase-likesearch Phosphoenolpyruvate-binding domainssearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B, C, D (P9WKK6) catalytic activitysearch isocitrate lyase activitysearch lyase activitysearch carboxylic acid metabolic processsearch glyoxylate cyclesearch tricarboxylic acid cyclesearch metabolic processsearch cytoplasmsearch

Chain InterPro annotation
A, B, C, D Isocitrate lyasesearch Pyruvate/Phosphoenolpyruvate kinase-like domainsearch Isocitrate lyase/phosphorylmutase, conserved sitesearch