1f8d Summary


Native Influenza Neuraminidase in Complex with 9-amino-2-deoxy-2,3-dehydro-N-neuraminic Acid

The structure was published by Smith, B.J., Colman, P.M., Von Itzstein, M., Danylec, B., and Varghese, J.N., in 2001 in a paper entitled "Analysis of inhibitor binding in influenza virus neuraminidase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.4 Å and deposited in 2000.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of NEURAMINIDASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A NEURAMINIDASE P03472 (83-470) (NRAM_I75A5)search Influenza A virus (A/tern/Australia/G70C/1975(H11N9))search < 90% 388 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P03472 (83 - 470) NEURAMINIDASE Influenza A virus (A/tern/Australia/G70C/1975(H11N9))

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Sialidases (neuraminidases)search Neuraminidasesearch Neuraminidasesearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (P03472) virion membranesearch membranesearch host cell membranesearch carbohydrate metabolic processsearch exo-alpha-sialidase activitysearch

Chain InterPro annotation
A Glycoside hydrolase, family 34search Sialidasessearch