› 1f8a

X-ray diffraction
1.84Å resolution

STRUCTURAL BASIS FOR THE PHOSPHOSERINE-PROLINE RECOGNITION BY GROUP IV WW DOMAINS

Released:
DOI: 10.2210/pdb1f8a/pdb
PDB entry 1f8a coloured by chain, front view.
PDB entry 1f8a coloured by chain, side view.
PDB entry 1f8a coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for phosphoserine-proline recognition by group IV WW domains.
Verdecia MA, Bowman ME, Lu KP, Hunter T, Noel JP
Nat Struct Biol 7 639-43 (2000)
PMID: 10932246

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-162178 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Chain: B
Molecule details ›
Chain: B
Length: 167 amino acids
Theoretical weight: 18.61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13526 (Residues: 1-163; Coverage: 100%)
Gene name: PIN1
Sequence domains:
Structure domains:
Y(SEP)PT(SEP)S PEPTIDE Chain: C
Molecule details ›
Chain: C
Length: 7 amino acids
Theoretical weight: 898 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
1 modified residue:
Ligand SEP 2 x SEP

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-1
Spacegroup: P212121
Unit cell:
a: 35.27Å b: 43.903Å c: 124.659Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.231 0.231 0.271
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

89 review citations

Validating survivin as a cancer therapeutic target.
Altieri DC. (2003)
88 more

43 mentions without citation

The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition.
Gareau et al. (2010)
42 more