1f42 Summary

pdbe.org/1f42
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THE P40 DOMAIN OF HUMAN INTERLEUKIN-12

The structure was published by Yoon, C., Johnston, S.C., Tang, J., Stahl, M., Tobin, J.F., and Somers, W.S., in 2000 in a paper entitled "Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin-12." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2000.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of INTERLEUKIN-12 BETA CHAIN. This molecule has the UniProt identifier P29460 (IL12B_HUMAN)search. The sample contained 306 residues which is 100% of the natural sequence. Out of 306 residues 293 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A INTERLEUKIN-12 BETA CHAIN P29460 (23-328) (IL12B_HUMAN)search Homo sapienssearch 100% 306 97%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P29460 (23 - 328) INTERLEUKIN-12 BETA CHAIN Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P29460) I set domainssearch, Fibronectin type IIIsearch Immunoglobulinssearch PF10420: Cytokine interleukin-12p40 C-terminussearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P29460) cytokine receptor activitysearch interleukin-12 alpha subunit bindingsearch protein bindingsearch identical protein bindingsearch protein heterodimerization activitysearch cytokine activitysearch interleukin-12 receptor bindingsearch growth factor activitysearch interleukin-23 receptor bindingsearch protein homodimerization activitysearch cytokine receptor bindingsearch extracellular spacesearch interleukin-12 complexsearch extracellular regionsearch interleukin-23 complexsearch cytoplasmsearch membranesearch negative regulation of smooth muscle cell proliferationsearch sensory perception of painsearch defense response to protozoansearch positive regulation of activated T cell proliferationsearch positive regulation of natural killer cell activationsearch positive regulation of inflammatory responsesearch natural killer cell activation involved in immune responsesearch positive regulation of T cell proliferationsearch negative regulation of interleukin-10 productionsearch positive regulation of interferon-gamma productionsearch defense response to Gram-negative bacteriumsearch positive regulation of NK T cell activationsearch positive regulation of tissue remodelingsearch positive regulation of T-helper 17 cell lineage commitmentsearch negative regulation of growth of symbiont in hostsearch interferon-gamma biosynthetic processsearch positive regulation of tyrosine phosphorylation of Stat4 proteinsearch positive regulation of tyrosine phosphorylation of Stat5 proteinsearch positive regulation of interleukin-12 productionsearch positive regulation of activation of JAK2 kinase activitysearch cellular response to interferon-gammasearch positive regulation of NF-kappaB import into nucleussearch positive regulation of osteoclast differentiationsearch cell surface receptor signaling pathwaysearch cell migrationsearch positive regulation of smooth muscle cell apoptotic processsearch positive regulation of tyrosine phosphorylation of Stat3 proteinsearch positive regulation of interleukin-17 productionsearch positive regulation of T-helper 1 type immune responsesearch positive regulation of memory T cell differentiationsearch cytokine-mediated signaling pathwaysearch positive regulation of granulocyte macrophage colony-stimulating factor productionsearch positive regulation of cell adhesionsearch cell cycle arrestsearch positive regulation of interleukin-10 productionsearch natural killer cell activationsearch positive regulation of lymphocyte proliferationsearch positive regulation of tumor necrosis factor productionsearch regulation of tyrosine phosphorylation of Stat1 proteinsearch positive regulation of defense response to virus by hostsearch sexual reproductionsearch negative regulation of inflammatory response to antigenic stimulussearch regulation of cytokine biosynthetic processsearch T-helper cell differentiationsearch positive regulation of mononuclear cell proliferationsearch positive regulation of natural killer cell proliferationsearch positive regulation of T cell mediated cytotoxicitysearch defense response to virussearch positive regulation of T-helper 17 type immune responsesearch T-helper 1 type immune responsesearch positive regulation of interferon-gamma biosynthetic processsearch negative regulation of interleukin-17 productionsearch positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell targetsearch cellular response to lipopolysaccharidesearch response to UV-Bsearch positive regulation of NK T cell proliferationsearch

Chain InterPro annotation
A Long hematopoietin receptor, soluble alpha chain, conserved sitesearch Immunoglobulin subtype 2search Fibronectin type IIIsearch Immunoglobulin-like domainsearch Immunoglobulin-like foldsearch Interleukin-12 betasearch Interleukin-12 beta, central domainsearch