EC 5.2.1.8: Peptidylprolyl isomerase
Reaction catalysed:
Peptidylproline (omega=180) = peptidylproline (omega=0)
Systematic name:
Peptidylproline cis-trans-isomerase
Alternative Name(s):
- Cyclophilin
- PPIase
- Peptide bond isomerase
- Peptidyl-prolyl cis-trans isomerase
- Peptidylprolyl cis-trans isomerase
- Rotamase
GO terms
Biochemical function:
- activin receptor binding
- I-SMAD binding
- transmembrane transporter binding
- type I transforming growth factor beta receptor binding
- signaling receptor inhibitor activity
- calcium channel inhibitor activity
- isomerase activity
- FK506 binding
- macrolide binding
- protein binding
- transforming growth factor beta receptor binding
- peptidyl-prolyl cis-trans isomerase activity
Biological process:
- amyloid fibril formation
- regulation of amyloid precursor protein catabolic process
- supramolecular fiber organization
- calcium ion transmembrane transport
- heart trabecula formation
- negative regulation of ryanodine-sensitive calcium-release channel activity
- regulation of ryanodine-sensitive calcium-release channel activity
- ventricular cardiac muscle tissue morphogenesis
- negative regulation of release of sequestered calcium ion into cytosol
- regulation of immune response
- positive regulation of canonical NF-kappaB signal transduction
- T cell activation
- protein refolding
- negative regulation of activin receptor signaling pathway
- regulation of protein localization
- negative regulation of phosphoprotein phosphatase activity
- positive regulation of protein binding
- negative regulation of transforming growth factor beta receptor signaling pathway
- protein maturation by protein folding
- 'de novo' protein folding
- protein folding
- heart morphogenesis
- protein peptidyl-prolyl isomerization
Protein family (Pfam)
InterPro annotations
CATH domain
SCOP annotation