1f2f Summary

pdbe.org/1f2f
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SRC SH2 THREF1TRP MUTANT

The structure was published by Kimber, M.S., Nachman, J., Cunningham, A.M., Gish, G.D., Pawson, T., and Pai, E.F., in 2000 in a paper entitled "Structural basis for specificity switching of the Src SH2 domain." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.7 Å and deposited in 2000.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC. This molecule has the UniProt identifier P00523 (SRC_CHICK)search. The sample contained 104 residues which is < 90% of the natural sequence. Out of 104 residues 104 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC P00523 (145-247) (SRC_CHICK)search Gallus gallussearch < 90% 104 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00523 (145 - 247) PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC Gallus gallus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A SH2 domainsearch SHC Adaptor Proteinsearch SH2 domainsearch
Chain InterPro annotation
A SH2 domainsearch