1f1w Summary

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SRC SH2 THREF1TRP MUTANT COMPLEXED WITH THE PHOSPHOPEPTIDE S(PTR)VNVQN

The structure was published by Kimber, M.S., Nachman, J., Cunningham, A.M., Gish, G.D., Pawson, T., and Pai, E.F., in 2000 in a paper entitled "Structural basis for specificity switching of the Src SH2 domain." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2000.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC and S(PTR)VNVQN PHOSPHOPEPTIDE.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC P00523 (145-247) (SRC_CHICK)search Gallus gallussearch < 90% 104 100%
B S(PTR)VNVQN PHOSPHOPEPTIDE Not available
Synthetic Not available 7 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00523 (145 - 247) PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC Gallus gallus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A SH2 domainsearch SHC Adaptor Proteinsearch SH2 domainsearch
B
Chain InterPro annotation
A SH2 domainsearch
B