1ey2 Summary



The structure was published by Titus, G.P., Mueller, H.A., Burgner, J., Rodriguez De Cordoba, S., Penalva, M.A., and Timm, D.E., in 2000 in a paper entitled "Crystal structure of human homogentisate dioxygenase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2000.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of HOMOGENTISATE 1,2-DIOXYGENASE. This molecule has the UniProt identifier Q93099 (HGD_HUMAN)search. The sample contained 471 residues which is 100% of the natural sequence. Out of 471 residues 419 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homohexamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HOMOGENTISATE 1,2-DIOXYGENASE Q93099 (1-445) (HGD_HUMAN)search Homo sapienssearch 100% 471 88%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q93099 (1 - 445) HOMOGENTISATE 1,2-DIOXYGENASE Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q93099) Homogentisate dioxygenasesearch Jelly Rollssearch PF04209: homogentisate 1,2-dioxygenasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (Q93099) oxidation-reduction processsearch L-phenylalanine catabolic processsearch cellular nitrogen compound metabolic processsearch tyrosine metabolic processsearch small molecule metabolic processsearch cellular amino acid metabolic processsearch tyrosine catabolic processsearch extracellular vesicular exosomesearch cytosolsearch metal ion bindingsearch homogentisate 1,2-dioxygenase activitysearch oxidoreductase activitysearch dioxygenase activitysearch

Chain InterPro annotation
A Homogentisate 1,2-dioxygenasesearch RmlC-like cupin domainsearch RmlC-like jelly roll foldsearch