1exa Summary

pdbe.org/1exa
spacer

ENANTIOMER DISCRIMINATION ILLUSTRATED BY CRYSTAL STRUCTURES OF THE HUMAN RETINOIC ACID RECEPTOR HRARGAMMA LIGAND BINDING DOMAIN: THE COMPLEX WITH THE ACTIVE R-ENANTIOMER BMS270394.

The structure was published by Klaholz, B.P., Mitschler, A., Belema, M., Zusi, C., and Moras, D., in 2000 in a paper entitled "Enantiomer discrimination illustrated by high-resolution crystal structures of the human nuclear receptor hRARgamma." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.59 Å and deposited in 2000.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of RETINOIC ACID RECEPTOR GAMMA-2. This molecule has the UniProt identifier P13631 (RARG_HUMAN)search. The sample contained 246 residues which is < 90% of the natural sequence. Out of 246 residues 236 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A RETINOIC ACID RECEPTOR GAMMA-2 P13631 (178-423) (RARG_HUMAN)search Homo sapienssearch < 90% 246 95%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P13631 (178 - 423) RETINOIC ACID RECEPTOR GAMMA-2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P13631) regulation of transcription, DNA-templatedsearch retinoic acid receptor signaling pathwaysearch steroid hormone mediated signaling pathwaysearch sequence-specific DNA binding transcription factor activitysearch steroid hormone receptor activitysearch DNA bindingsearch retinoic acid receptor activitysearch nucleussearch

Chain InterPro annotation
A Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Retinoic acid receptorsearch Nuclear hormone receptor, ligand-bindingsearch