1ev6 Summary

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Structure of the monoclinic form of the M-cresol/insulin R6 hexamer

The structure was published by Smith, G.D., Ciszak, E., Magrum, L.A., Pangborn, W.A., and Blessing, R.H., in 2000 in a paper entitled "R6 Hexameric Insulin Complexed with m-Cresol or Resorcinol" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2000.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely INSULIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The most likely quaternary structure is a 12meric assembly.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A INSULIN P01308 (90-110) (INS_HUMAN)search Homo sapienssearch 100% 21 100%
C INSULIN P01308 (90-110) (INS_HUMAN)search Homo sapienssearch 100% 21 100%
E INSULIN P01308 (90-110) (INS_HUMAN)search Homo sapienssearch 100% 21 100%
G INSULIN P01308 (90-110) (INS_HUMAN)search Homo sapienssearch 100% 21 100%
I INSULIN P01308 (90-110) (INS_HUMAN)search Homo sapienssearch 100% 21 100%
K INSULIN P01308 (90-110) (INS_HUMAN)search Homo sapienssearch 100% 21 100%
B INSULIN P01308 (25-54) (INS_HUMAN)search Homo sapienssearch 100% 30 100%
D INSULIN P01308 (25-54) (INS_HUMAN)search Homo sapienssearch 100% 30 100%
F INSULIN P01308 (25-54) (INS_HUMAN)search Homo sapienssearch 100% 30 100%
H INSULIN P01308 (25-54) (INS_HUMAN)search Homo sapienssearch 100% 30 100%
J INSULIN P01308 (25-54) (INS_HUMAN)search Homo sapienssearch 100% 30 100%
L INSULIN P01308 (25-54) (INS_HUMAN)search Homo sapienssearch 100% 30 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P01308 (90 - 110) INSULIN

Chain Structural classification (SCOP) Sequence family (Pfam)
A, C, E, G, I, K (P01308) Insulin-likesearch PF00049: Insulin/IGF/Relaxin familysearch
B, D, F, H, J, L (P01308) Insulin-likesearch PF00049: Insulin/IGF/Relaxin familysearch
Chain InterPro annotation
A, C, E, G, I, K Insulin-likesearch Insulin, conserved sitesearch
B, D, F, H, J, L Insulinsearch Insulin-likesearch