1euu Summary

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SIALIDASE OR NEURAMINIDASE, LARGE 68KD FORM

The structure was published by Gaskell, A., Crennell, S., and Taylor, G., in 1995 in a paper entitled "The three domains of a bacterial sialidase: a beta-propeller, an immunoglobulin module and a galactose-binding jelly-roll." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 1996.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of SIALIDASE. This molecule has the UniProt identifier Q02834 (NANH_MICVI)search. The sample contained 605 residues which is 99% of the natural sequence. Out of 605 residues 601 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A SIALIDASE Q02834 (43-647) (NANH_MICVI)search Micromonospora viridifacienssearch 99% 605 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q02834 (43 - 647) SIALIDASE Micromonospora viridifaciens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q02834) E-set domains of sugar-utilizing enzymessearch, Galactose-binding domainsearch, Sialidases (neuraminidases)search Neuraminidasesearch, Immunoglobulinssearch, Galactose-binding domain-likesearch PF00754: F5/8 type C domainsearch, PF10633: NPCBM-associated, NEW3 domain of alpha-galactosidasesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (Q02834) exo-alpha-(2->8)-sialidase activitysearch exo-alpha-(2->6)-sialidase activitysearch hydrolase activitysearch hydrolase activity, acting on glycosyl bondssearch exo-alpha-sialidase activitysearch exo-alpha-(2->3)-sialidase activitysearch extracellular regionsearch metabolic processsearch cell adhesionsearch

Chain InterPro annotation
A Coagulation factor 5/8 C-terminal type domainsearch Galactose-binding domain-likesearch Sialidasessearch Immunoglobulin-like foldsearch Immunoglobulin E-setsearch Alpha-galactosidase, NEW3 domainsearch Sialidase familysearch