1eqz Summary

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X-RAY STRUCTURE OF THE NUCLEOSOME CORE PARTICLE AT 2.5 A RESOLUTION

The structure was published by Harp, J.M., Hanson, B.L., Timm, D.E., and Bunick, G.J., in 2000 in a paper entitled "Asymmetries in the nucleosome core particle at 2.5 A resolution." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2000.

The experimental data on which the structure is based was not deposited.

This entry contains 45 copies of 5 unique biopolymers (complete list).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodecamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (HISTONE H2A) P02263 (1-129) (H2A4_CHICK)search Gallus gallussearch 99% 129 98%
E PROTEIN (HISTONE H2A) P02263 (1-129) (H2A4_CHICK)search Gallus gallussearch 99% 129 98%
B PROTEIN (HISTONE H2B) P0C1H5 (1-126) (H2B7_CHICK)search Gallus gallussearch 99% 126 85%
F PROTEIN (HISTONE H2B) P0C1H5 (1-126) (H2B7_CHICK)search Gallus gallussearch 99% 126 85%
C PROTEIN (HISTONE H3) P84229 (1-136) (H32_CHICK)search Gallus gallussearch 99% 136 88%
G PROTEIN (HISTONE H3) P84229 (1-136) (H32_CHICK)search Gallus gallussearch 99% 136 88%
D PROTEIN (HISTONE H4) P62801 (1-103) (H4_CHICK)search Gallus gallussearch 99% 103 92%
H PROTEIN (HISTONE H4) P62801 (1-103) (H4_CHICK)search Gallus gallussearch 99% 103 92%


This entry contains 4 unique UniProt proteins:

UniProt accession Name Organism PDB
P02263 (1 - 129) PROTEIN (HISTONE H2A) Gallus gallus
P0C1H5 (1 - 126) PROTEIN (HISTONE H2B) Gallus gallus
P84229 (1 - 136) PROTEIN (HISTONE H3) Gallus gallus
P62801 (1 - 103) PROTEIN (HISTONE H4) Gallus gallus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, E (P02263) Nucleosome core histonessearch Histone, subunit Asearch PF00125: Core histone H2A/H2B/H3/H4search
B, F (P0C1H5) Nucleosome core histonessearch Histone, subunit Asearch PF00125: Core histone H2A/H2B/H3/H4search
C, G (P84229) Nucleosome core histonessearch Histone, subunit Asearch PF00125: Core histone H2A/H2B/H3/H4search
D, H (P62801) Nucleosome core histonessearch Histone, subunit Asearch PF00125: Core histone H2A/H2B/H3/H4search

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, E (P02263) nucleosomesearch nucleussearch chromosomesearch DNA bindingsearch protein heterodimerization activitysearch
B, F (P0C1H5) NuA4 histone acetyltransferase complexsearch nucleosomesearch nucleussearch chromosomesearch lipid particlesearch DNA bindingsearch protein heterodimerization activitysearch
C, G (P84229) nucleosomesearch nucleussearch chromosomesearch DNA bindingsearch protein heterodimerization activitysearch
D, H (P62801) nuclear chromosomesearch nucleosomesearch nucleussearch nucleoplasmsearch chromosomesearch membranesearch protein complexsearch extracellular vesicular exosomesearch DNA bindingsearch poly(A) RNA bindingsearch protein heterodimerization activitysearch nucleosome assemblysearch DNA replication-dependent nucleosome assemblysearch DNA replication-independent nucleosome assemblysearch DNA-templated transcription, initiationsearch negative regulation of megakaryocyte differentiationsearch

Chain InterPro annotation
A, E Histone H2Asearch Histone coresearch Histone-foldsearch
B, F Histone H2Bsearch Histone coresearch Histone-foldsearch
C, G Histone H3/CENP-Asearch Histone coresearch Histone-foldsearch
D, H Histone H4search Histone coresearch Histone-foldsearch Histone H4, conserved sitesearch