1eo3 Summary

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INHIBITION OF ECORV ENDONUCLEASE BY DEOXYRIBO-3'-S-PHOSPHOROTHIOLATES: A HIGH RESOLUTION X-RAY CRYSTALLOGRAPHIC STUDY

The structure was published by Horton, N.C., Connolly, B.A., and Perona, J.J., in 2000 in a paper entitled "Inhibition of EcoRV Endonuclease by Deoxyribo-3'-S-phosphorothiolates: A High-Resolution X-ray Crystallographic Study" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2000.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely DNA (5'-D(*CP*AP*AP*GP*AP*(TSP)P*AP*TP*CP*TP*T)-3') and TYPE II RESTRICTION ENZYME ECORV.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A TYPE II RESTRICTION ENZYME ECORV P04390 (1-245) (T2E5_ECOLX)search Escherichia colisearch 100% 245 98%
B TYPE II RESTRICTION ENZYME ECORV P04390 (1-245) (T2E5_ECOLX)search Escherichia colisearch 100% 245 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P04390 (1 - 245) TYPE II RESTRICTION ENZYME ECORV Escherichia coli

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P04390) Restriction endonuclease EcoRVsearch ECO RV Endonuclease; Chain Asearch PF09233: Restriction endonuclease EcoRVsearch

Chain ID Biological process (GO) Molecular function (GO)
A, B (P04390) DNA catabolic process, endonucleolyticsearch DNA restriction-modification systemsearch nucleic acid phosphodiester bond hydrolysissearch DNA bindingsearch nuclease activitysearch endonuclease activitysearch Type II site-specific deoxyribonuclease activitysearch hydrolase activitysearch metal ion bindingsearch

Chain InterPro annotation
A, B Restriction endonuclease type II-likesearch DNA mismatch repair MutH/Restriction endonuclease, type IIsearch Restriction endonuclease, type II, EcoRVsearch Restriction endonuclease, type II, EcoRV, Proteobacteriasearch