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CRYSTAL STRUCTURE OF A BIOLOGICALLY ACTIVE SINGLE CHAIN MUTANT OF HUMAN IFN-GAMMA

The structure was published by Landar, A., Curry, B., Parker, M.H., et al., Nagabhushan, T.L., Rizzi, G., and Walter, M.R., in 2000 in a paper entitled "Design, characterization, and structure of a biologically active single-chain mutant of human IFN-gamma." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2000.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of INTERFERON GAMMA.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A INTERFERON GAMMA P01579 (26-161) (IFNG_HUMAN)search Homo sapienssearch 90% 265 95%
B INTERFERON GAMMA P01579 (26-161) (IFNG_HUMAN)search Homo sapienssearch 90% 265 95%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P01579 (26 - 161) INTERFERON GAMMA Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P01579) Interferons/interleukin-10 (IL-10)search Growth Hormone; Chain: A;search PF00714: Interferon gammasearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, B (P01579) extracellular regionsearch extracellular spacesearch external side of plasma membranesearch positive regulation of interleukin-12 biosynthetic processsearch interferon-gamma-mediated signaling pathwaysearch humoral immune responsesearch neutrophil apoptotic processsearch positive regulation of tyrosine phosphorylation of Stat1 proteinsearch positive regulation of tumor necrosis factor (ligand) superfamily member 11 productionsearch regulation of interferon-gamma-mediated signaling pathwaysearch positive regulation of calcidiol 1-monooxygenase activitysearch positive regulation of isotype switching to IgG isotypessearch positive regulation of T cell proliferationsearch apoptotic processsearch positive regulation of MHC class II biosynthetic processsearch negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesissearch positive regulation of smooth muscle cell apoptotic processsearch negative regulation of cell proliferationsearch defense response to virussearch positive regulation of interleukin-12 productionsearch negative regulation of transcription from RNA polymerase II promotersearch cellular component movementsearch cell surface receptor signaling pathwaysearch cellular response to interleukin-18search positive regulation of fructose 1,6-bisphosphate metabolic processsearch defense response to protozoansearch negative regulation of myelinationsearch positive regulation of killing of cells of other organismsearch positive regulation of synaptic transmission, cholinergicsearch positive regulation of vitamin D biosynthetic processsearch positive regulation of cell proliferationsearch response to drugsearch CD8-positive, alpha-beta T cell differentiation involved in immune responsesearch cytokine-mediated signaling pathwaysearch negative regulation of interleukin-17 productionsearch positive regulation of neuron differentiationsearch extrinsic apoptotic signaling pathwaysearch positive regulation of interleukin-1 beta secretionsearch adaptive immune responsesearch cell cycle arrestsearch negative regulation of smooth muscle cell proliferationsearch negative regulation of epithelial cell differentiationsearch neutrophil chemotaxissearch positive regulation of cell adhesionsearch response to virussearch inflammatory cell apoptotic processsearch defense response to bacteriumsearch regulation of growthsearch positive regulation of transcription, DNA-templatedsearch protein import into nucleus, translocationsearch positive regulation of peptidyl-serine phosphorylation of STAT proteinsearch positive regulation of nitric oxide biosynthetic processsearch positive regulation of interleukin-6 biosynthetic processsearch positive regulation of mesenchymal cell proliferationsearch positive regulation of fructose 1,6-bisphosphate 1-phosphatase activitysearch regulation of the force of heart contractionsearch endoplasmic reticulum unfolded protein responsesearch positive regulation of interleukin-23 productionsearch antigen processing and presentationsearch positive regulation of osteoclast differentiationsearch regulation of insulin secretionsearch positive regulation of transcription from RNA polymerase II promotersearch positive regulation of chemokine biosynthetic processsearch regulation of transcription, DNA-templatedsearch negative regulation of growth of symbiont in hostsearch negative regulation of growth of symbiont involved in interaction with hostsearch positive regulation of tumor necrosis factor productionsearch positive regulation of membrane protein ectodomain proteolysissearch negative regulation of metanephric nephron tubule epithelial cell differentiationsearch regulation of immune responsesearch cellular response to lipopolysaccharidesearch immune responsesearch cytokine activitysearch interferon-gamma receptor bindingsearch

Chain InterPro annotation
A, B Interferon gammasearch Four-helical cytokine-like, coresearch Four-helical cytokine, coresearch