1eku Summary

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CRYSTAL STRUCTURE OF A BIOLOGICALLY ACTIVE SINGLE CHAIN MUTANT OF HUMAN IFN-GAMMA

The structure was published by Landar, A., Curry, B., Parker, M.H., et al., Nagabhushan, T.L., Rizzi, G., and Walter, M.R., in 2000 in a paper entitled "Design, characterization, and structure of a biologically active single-chain mutant of human IFN-gamma." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2000.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of INTERFERON GAMMA.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A INTERFERON GAMMA P01579 (26-161) (IFNG_HUMAN)search Homo sapienssearch 90% 265 95%
B INTERFERON GAMMA P01579 (26-161) (IFNG_HUMAN)search Homo sapienssearch 90% 265 95%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P01579 (26 - 161) INTERFERON GAMMA Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P01579) Interferons/interleukin-10 (IL-10)search Growth Hormone; Chain: A;search PF00714: Interferon gammasearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P01579) interferon-gamma receptor bindingsearch cytokine activitysearch interferon-gamma-mediated signaling pathwaysearch positive regulation of tumor necrosis factor productionsearch positive regulation of tyrosine phosphorylation of Stat1 proteinsearch positive regulation of interleukin-6 biosynthetic processsearch positive regulation of interleukin-1 beta secretionsearch negative regulation of metanephric nephron tubule epithelial cell differentiationsearch negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesissearch positive regulation of T cell proliferationsearch negative regulation of growth of symbiont in hostsearch negative regulation of growth of symbiont involved in interaction with hostsearch positive regulation of neuron differentiationsearch defense response to protozoansearch regulation of interferon-gamma-mediated signaling pathwaysearch antigen processing and presentationsearch positive regulation of tumor necrosis factor (ligand) superfamily member 11 productionsearch positive regulation of calcidiol 1-monooxygenase activitysearch response to drugsearch positive regulation of isotype switching to IgG isotypessearch positive regulation of transcription, DNA-templatedsearch negative regulation of transcription from RNA polymerase II promotersearch positive regulation of cell proliferationsearch apoptotic processsearch defense response to bacteriumsearch neutrophil apoptotic processsearch defense response to virussearch positive regulation of chemokine biosynthetic processsearch positive regulation of smooth muscle cell apoptotic processsearch positive regulation of transcription from RNA polymerase II promotersearch positive regulation of fructose 1,6-bisphosphate metabolic processsearch positive regulation of interleukin-12 productionsearch positive regulation of killing of cells of other organismsearch regulation of neuronal action potentialsearch positive regulation of cell adhesionsearch movement of cell or subcellular componentsearch cell surface receptor signaling pathwaysearch sensory perception of mechanical stimulussearch positive regulation of vitamin D biosynthetic processsearch regulation of the force of heart contractionsearch humoral immune responsesearch regulation of growthsearch positive regulation of osteoclast differentiationsearch regulation of transcription, DNA-templatedsearch positive regulation of peptidyl-serine phosphorylation of STAT proteinsearch negative regulation of myelinationsearch cytokine-mediated signaling pathwaysearch extrinsic apoptotic signaling pathwaysearch positive regulation of synaptic transmission, cholinergicsearch positive regulation of MHC class II biosynthetic processsearch cell cycle arrestsearch negative regulation of smooth muscle cell proliferationsearch negative regulation of epithelial cell differentiationsearch CD8-positive, alpha-beta T cell differentiation involved in immune responsesearch negative regulation of interleukin-17 productionsearch adaptive immune responsesearch response to virussearch positive regulation of mesenchymal cell proliferationsearch inflammatory cell apoptotic processsearch cellular response to interleukin-18search protein import into nucleus, translocationsearch positive regulation of interleukin-12 biosynthetic processsearch positive regulation of nitric oxide biosynthetic processsearch regulation of hepatocyte proliferationsearch negative regulation of cell proliferationsearch positive regulation of fructose 1,6-bisphosphate 1-phosphatase activitysearch positive regulation of interleukin-23 productionsearch regulation of immune responsesearch neutrophil chemotaxissearch regulation of insulin secretionsearch positive regulation of membrane protein ectodomain proteolysissearch endoplasmic reticulum unfolded protein responsesearch positive regulation of epithelial cell migrationsearch cellular response to lipopolysaccharidesearch immune responsesearch extracellular regionsearch extracellular spacesearch external side of plasma membranesearch

Chain InterPro annotation
A, B Interferon gammasearch Four-helical cytokine-like, coresearch Four-helical cytokine, coresearch