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CRYSTAL STRUCTURE OF A BIOLOGICALLY ACTIVE SINGLE CHAIN MUTANT OF HUMAN IFN-GAMMA

The structure was published by Landar, A., Curry, B., Parker, M.H., et al., Nagabhushan, T.L., Rizzi, G., and Walter, M.R., in 2000 in a paper entitled "Design, characterization, and structure of a biologically active single-chain mutant of human IFN-gamma." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2000.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of INTERFERON GAMMA.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A INTERFERON GAMMA P01579 (26-161) (IFNG_HUMAN)search Homo sapienssearch 90% 265 95%
B INTERFERON GAMMA P01579 (26-161) (IFNG_HUMAN)search Homo sapienssearch 90% 265 95%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P01579 (26 - 161) INTERFERON GAMMA Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P01579) Interferons/interleukin-10 (IL-10)search Growth Hormone; Chain: A;search PF00714: Interferon gammasearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, B (P01579) extracellular regionsearch extracellular spacesearch external side of plasma membranesearch sensory perception of mechanical stimulussearch positive regulation of osteoclast differentiationsearch apoptotic processsearch regulation of hepatocyte proliferationsearch cellular response to interleukin-18search extrinsic apoptotic signaling pathwaysearch response to virussearch cytokine-mediated signaling pathwaysearch endoplasmic reticulum unfolded protein responsesearch negative regulation of interleukin-17 productionsearch negative regulation of growth of symbiont in hostsearch cell cycle arrestsearch negative regulation of smooth muscle cell proliferationsearch negative regulation of epithelial cell differentiationsearch negative regulation of metanephric nephron tubule epithelial cell differentiationsearch positive regulation of peptidyl-serine phosphorylation of STAT proteinsearch antigen processing and presentationsearch regulation of immune responsesearch adaptive immune responsesearch regulation of growthsearch CD8-positive, alpha-beta T cell differentiation involved in immune responsesearch regulation of insulin secretionsearch positive regulation of tumor necrosis factor productionsearch humoral immune responsesearch negative regulation of growth of symbiont involved in interaction with hostsearch positive regulation of fructose 1,6-bisphosphate 1-phosphatase activitysearch positive regulation of interleukin-23 productionsearch protein import into nucleus, translocationsearch positive regulation of interleukin-12 productionsearch positive regulation of membrane protein ectodomain proteolysissearch positive regulation of neuron differentiationsearch positive regulation of transcription from RNA polymerase II promotersearch regulation of the force of heart contractionsearch neutrophil chemotaxissearch neutrophil apoptotic processsearch inflammatory cell apoptotic processsearch positive regulation of nitric oxide biosynthetic processsearch immune responsesearch negative regulation of cell proliferationsearch defense response to virussearch positive regulation of MHC class II biosynthetic processsearch positive regulation of chemokine biosynthetic processsearch positive regulation of tumor necrosis factor (ligand) superfamily member 11 productionsearch positive regulation of calcidiol 1-monooxygenase activitysearch regulation of interferon-gamma-mediated signaling pathwaysearch positive regulation of interleukin-6 biosynthetic processsearch positive regulation of tyrosine phosphorylation of Stat1 proteinsearch interferon-gamma-mediated signaling pathwaysearch negative regulation of myelinationsearch negative regulation of transcription from RNA polymerase II promotersearch response to drugsearch positive regulation of interleukin-12 biosynthetic processsearch positive regulation of isotype switching to IgG isotypessearch positive regulation of cell adhesionsearch regulation of transcription, DNA-templatedsearch positive regulation of smooth muscle cell apoptotic processsearch positive regulation of T cell proliferationsearch positive regulation of transcription, DNA-templatedsearch positive regulation of vitamin D biosynthetic processsearch positive regulation of killing of cells of other organismsearch cellular response to lipopolysaccharidesearch negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesissearch positive regulation of fructose 1,6-bisphosphate metabolic processsearch movement of cell or subcellular componentsearch cell surface receptor signaling pathwaysearch defense response to bacteriumsearch positive regulation of mesenchymal cell proliferationsearch positive regulation of interleukin-1 beta secretionsearch positive regulation of synaptic transmission, cholinergicsearch regulation of neuronal action potentialsearch positive regulation of cell proliferationsearch defense response to protozoansearch cytokine activitysearch interferon-gamma receptor bindingsearch

Chain InterPro annotation
A, B Interferon gammasearch Four-helical cytokine-like, coresearch Four-helical cytokine, coresearch