1eku Summary

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CRYSTAL STRUCTURE OF A BIOLOGICALLY ACTIVE SINGLE CHAIN MUTANT OF HUMAN IFN-GAMMA

The structure was published by Landar, A., Curry, B., Parker, M.H., et al., Nagabhushan, T.L., Rizzi, G., and Walter, M.R., in 2000 in a paper entitled "Design, characterization, and structure of a biologically active single-chain mutant of human IFN-gamma." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2000.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of INTERFERON GAMMA.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A INTERFERON GAMMA P01579 (26-161) (IFNG_HUMAN)search Homo sapienssearch 90% 265 95%
B INTERFERON GAMMA P01579 (26-161) (IFNG_HUMAN)search Homo sapienssearch 90% 265 95%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P01579 (26 - 161) INTERFERON GAMMA Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P01579) Interferons/interleukin-10 (IL-10)search Growth Hormone; Chain: A;search PF00714: Interferon gammasearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, B (P01579) immune responsesearch positive regulation of synaptic transmission, cholinergicsearch negative regulation of transcription from RNA polymerase II promotersearch positive regulation of tyrosine phosphorylation of Stat1 proteinsearch negative regulation of cell proliferationsearch interferon-gamma-mediated signaling pathwaysearch neutrophil chemotaxissearch response to drugsearch positive regulation of tumor necrosis factor (ligand) superfamily member 11 productionsearch positive regulation of peptidyl-serine phosphorylation of STAT proteinsearch regulation of interferon-gamma-mediated signaling pathwaysearch positive regulation of calcidiol 1-monooxygenase activitysearch negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesissearch positive regulation of T cell proliferationsearch neutrophil apoptotic processsearch positive regulation of cell adhesionsearch humoral immune responsesearch positive regulation of vitamin D biosynthetic processsearch positive regulation of fructose 1,6-bisphosphate metabolic processsearch positive regulation of interleukin-12 productionsearch cellular component movementsearch cell surface receptor signaling pathwaysearch positive regulation of killing of cells of other organismsearch negative regulation of growth of symbiont involved in interaction with hostsearch positive regulation of neuron differentiationsearch apoptotic processsearch cellular response to lipopolysaccharidesearch positive regulation of mesenchymal cell proliferationsearch positive regulation of smooth muscle cell apoptotic processsearch defense response to virussearch cellular response to interleukin-18search defense response to bacteriumsearch positive regulation of tumor necrosis factor productionsearch negative regulation of growth of symbiont in hostsearch inflammatory cell apoptotic processsearch negative regulation of myelinationsearch positive regulation of osteoclast differentiationsearch negative regulation of metanephric nephron tubule epithelial cell differentiationsearch defense response to protozoansearch negative regulation of interleukin-17 productionsearch CD8-positive, alpha-beta T cell differentiation involved in immune responsesearch adaptive immune responsesearch endoplasmic reticulum unfolded protein responsesearch positive regulation of nitric oxide biosynthetic processsearch positive regulation of MHC class II biosynthetic processsearch extrinsic apoptotic signaling pathwaysearch response to virussearch positive regulation of interleukin-6 biosynthetic processsearch cell cycle arrestsearch negative regulation of smooth muscle cell proliferationsearch positive regulation of interleukin-1 beta secretionsearch cytokine-mediated signaling pathwaysearch positive regulation of chemokine biosynthetic processsearch positive regulation of transcription from RNA polymerase II promotersearch regulation of growthsearch positive regulation of membrane protein ectodomain proteolysissearch positive regulation of isotype switching to IgG isotypessearch positive regulation of transcription, DNA-templatedsearch regulation of transcription, DNA-templatedsearch regulation of insulin secretionsearch positive regulation of interleukin-23 productionsearch regulation of the force of heart contractionsearch positive regulation of fructose 1,6-bisphosphate 1-phosphatase activitysearch antigen processing and presentationsearch protein import into nucleus, translocationsearch positive regulation of interleukin-12 biosynthetic processsearch regulation of immune responsesearch extracellular regionsearch extracellular spacesearch external side of plasma membranesearch cytokine activitysearch interferon-gamma receptor bindingsearch

Chain InterPro annotation
A, B Interferon gammasearch Four-helical cytokine-like, coresearch Four-helical cytokine, coresearch