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CRYSTAL STRUCTURE OF A BIOLOGICALLY ACTIVE SINGLE CHAIN MUTANT OF HUMAN IFN-GAMMA

The structure was published by Landar, A., Curry, B., Parker, M.H., et al., Nagabhushan, T.L., Rizzi, G., and Walter, M.R., in 2000 in a paper entitled "Design, characterization, and structure of a biologically active single-chain mutant of human IFN-gamma." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2000.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of INTERFERON GAMMA.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A INTERFERON GAMMA P01579 (26-161) (IFNG_HUMAN)search Homo sapienssearch 90% 265 95%
B INTERFERON GAMMA P01579 (26-161) (IFNG_HUMAN)search Homo sapienssearch 90% 265 95%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P01579 (26 - 161) INTERFERON GAMMA Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P01579) Interferons/interleukin-10 (IL-10)search Growth Hormone; Chain: A;search PF00714: Interferon gammasearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P01579) protein import into nucleus, translocationsearch negative regulation of transcription from RNA polymerase II promotersearch neutrophil apoptotic processsearch regulation of the force of heart contractionsearch positive regulation of mesenchymal cell proliferationsearch adaptive immune responsesearch CD8-positive, alpha-beta T cell differentiation involved in immune responsesearch negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesissearch regulation of transcription, DNA-templatedsearch apoptotic processsearch inflammatory cell apoptotic processsearch cellular component movementsearch immune responsesearch humoral immune responsesearch cell cycle arrestsearch cell surface receptor signaling pathwaysearch positive regulation of cell proliferationsearch negative regulation of cell proliferationsearch response to virussearch cytokine-mediated signaling pathwaysearch antigen processing and presentationsearch neutrophil chemotaxissearch negative regulation of epithelial cell differentiationsearch endoplasmic reticulum unfolded protein responsesearch negative regulation of myelinationsearch positive regulation of synaptic transmission, cholinergicsearch negative regulation of interleukin-17 productionsearch positive regulation of interleukin-12 productionsearch positive regulation of interleukin-23 productionsearch positive regulation of tumor necrosis factor productionsearch positive regulation of peptidyl-serine phosphorylation of STAT proteinsearch positive regulation of smooth muscle cell apoptotic processsearch regulation of growthsearch positive regulation of T cell proliferationsearch response to drugsearch positive regulation of tyrosine phosphorylation of Stat1 proteinsearch defense response to bacteriumsearch defense response to protozoansearch negative regulation of growth of symbiont in hostsearch negative regulation of growth of symbiont involved in interaction with hostsearch positive regulation of chemokine biosynthetic processsearch positive regulation of interleukin-12 biosynthetic processsearch positive regulation of MHC class II biosynthetic processsearch positive regulation of interleukin-6 biosynthetic processsearch positive regulation of nitric oxide biosynthetic processsearch positive regulation of neuron differentiationsearch positive regulation of osteoclast differentiationsearch positive regulation of cell adhesionsearch positive regulation of transcription, DNA-templatedsearch positive regulation of transcription from RNA polymerase II promotersearch positive regulation of isotype switching to IgG isotypessearch negative regulation of smooth muscle cell proliferationsearch positive regulation of interleukin-1 beta secretionsearch regulation of immune responsesearch regulation of insulin secretionsearch positive regulation of membrane protein ectodomain proteolysissearch defense response to virussearch positive regulation of killing of cells of other organismsearch interferon-gamma-mediated signaling pathwaysearch regulation of interferon-gamma-mediated signaling pathwaysearch positive regulation of fructose 1,6-bisphosphate 1-phosphatase activitysearch positive regulation of fructose 1,6-bisphosphate metabolic processsearch positive regulation of vitamin D biosynthetic processsearch positive regulation of calcidiol 1-monooxygenase activitysearch cellular response to lipopolysaccharidesearch cellular response to interleukin-18search negative regulation of metanephric nephron tubule epithelial cell differentiationsearch extrinsic apoptotic signaling pathwaysearch positive regulation of tumor necrosis factor (ligand) superfamily member 11 productionsearch cytokine activitysearch interferon-gamma receptor bindingsearch extracellular regionsearch extracellular spacesearch external side of plasma membranesearch

Chain InterPro annotation
A, B Interferon gammasearch Four-helical cytokine-like, coresearch Four-helical cytokine, coresearch