1eku Summary

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CRYSTAL STRUCTURE OF A BIOLOGICALLY ACTIVE SINGLE CHAIN MUTANT OF HUMAN IFN-GAMMA

The structure was published by Landar, A., Curry, B., Parker, M.H., et al., Nagabhushan, T.L., Rizzi, G., and Walter, M.R., in 2000 in a paper entitled "Design, characterization, and structure of a biologically active single-chain mutant of human IFN-gamma." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2000.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of INTERFERON GAMMA.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A INTERFERON GAMMA P01579 (26-161) (IFNG_HUMAN)search Homo sapienssearch 90% 265 95%
B INTERFERON GAMMA P01579 (26-161) (IFNG_HUMAN)search Homo sapienssearch 90% 265 95%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P01579 (26 - 161) INTERFERON GAMMA Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P01579) Interferons/interleukin-10 (IL-10)search Growth Hormone; Chain: A;search PF00714: Interferon gammasearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, B (P01579) interferon-gamma-mediated signaling pathwaysearch negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesissearch defense response to virussearch humoral immune responsesearch endoplasmic reticulum unfolded protein responsesearch defense response to protozoansearch positive regulation of tyrosine phosphorylation of Stat1 proteinsearch positive regulation of interleukin-12 productionsearch positive regulation of interleukin-1 beta secretionsearch regulation of the force of heart contractionsearch inflammatory cell apoptotic processsearch positive regulation of calcidiol 1-monooxygenase activitysearch regulation of interferon-gamma-mediated signaling pathwaysearch positive regulation of smooth muscle cell apoptotic processsearch regulation of transcription, DNA-templatedsearch apoptotic processsearch positive regulation of tumor necrosis factor productionsearch regulation of hepatocyte proliferationsearch positive regulation of cell adhesionsearch positive regulation of isotype switching to IgG isotypessearch positive regulation of tumor necrosis factor (ligand) superfamily member 11 productionsearch positive regulation of neuron differentiationsearch negative regulation of metanephric nephron tubule epithelial cell differentiationsearch positive regulation of interleukin-12 biosynthetic processsearch negative regulation of transcription from RNA polymerase II promotersearch positive regulation of vitamin D biosynthetic processsearch regulation of immune responsesearch CD8-positive, alpha-beta T cell differentiation involved in immune responsesearch adaptive immune responsesearch cellular component movementsearch cell surface receptor signaling pathwaysearch positive regulation of killing of cells of other organismsearch positive regulation of fructose 1,6-bisphosphate metabolic processsearch cytokine-mediated signaling pathwaysearch positive regulation of T cell proliferationsearch regulation of neuronal action potentialsearch positive regulation of synaptic transmission, cholinergicsearch positive regulation of cell proliferationsearch response to virussearch negative regulation of growth of symbiont involved in interaction with hostsearch negative regulation of myelinationsearch cellular response to lipopolysaccharidesearch cell cycle arrestsearch negative regulation of smooth muscle cell proliferationsearch negative regulation of epithelial cell differentiationsearch negative regulation of interleukin-17 productionsearch cellular response to interleukin-18search extrinsic apoptotic signaling pathwaysearch positive regulation of chemokine biosynthetic processsearch positive regulation of MHC class II biosynthetic processsearch protein import into nucleus, translocationsearch positive regulation of osteoclast differentiationsearch positive regulation of interleukin-6 biosynthetic processsearch antigen processing and presentationsearch neutrophil chemotaxissearch neutrophil apoptotic processsearch positive regulation of peptidyl-serine phosphorylation of STAT proteinsearch defense response to bacteriumsearch regulation of insulin secretionsearch sensory perception of mechanical stimulussearch negative regulation of growth of symbiont in hostsearch positive regulation of transcription, DNA-templatedsearch positive regulation of interleukin-23 productionsearch positive regulation of mesenchymal cell proliferationsearch response to drugsearch negative regulation of cell proliferationsearch regulation of growthsearch positive regulation of fructose 1,6-bisphosphate 1-phosphatase activitysearch positive regulation of nitric oxide biosynthetic processsearch positive regulation of transcription from RNA polymerase II promotersearch positive regulation of membrane protein ectodomain proteolysissearch immune responsesearch extracellular regionsearch extracellular spacesearch external side of plasma membranesearch cytokine activitysearch interferon-gamma receptor bindingsearch

Chain InterPro annotation
A, B Interferon gammasearch Four-helical cytokine-like, coresearch Four-helical cytokine, coresearch